Histologic Diagnosis of Inflammatory Skin Diseases

Ground Substance

…ugh a conventional microscope, is not visualizable, only empty spaces being apparent between bundles of collagen. Specialized stains, such as colloidal iron and Alcian blue, are required to demonstrate the presence, albeit in scant amount, of acid mu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ibrin is not present in the wall of venules, as here, findings such as those pictured suffice for diagnosis of leukocytoclastic vasculitis. In short, the changes shown are specific for that condition. 10.58.2A: Perivascular and interstitial der…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…iosis lipoidica for mucin of granuloma annulare; the former is blue and amorphous, whereas the latter is blue and finely granular. Mucin is stained a brilliant aquamarine by colloidal iron, but degeneration of collagen is not stained by it at all. So…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…hes a diagnosis of pernio. Perniosis refers to a change in the skin that follows on a disturbance in blood vessels. It is manifested as discoloration from red to dark blue, succeeded by blisters and even ulceration in some patients. Chilblain lupus,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

…egeneration and are dispatched from their site original to the skin surface, where they reside temporarily in a neutrophil-containing crust atop an ulcer. In sections stained by hematoxylin and eosin, degenerated bundles of collagen appear blue rathe…

Histologic Diagnosis of Inflammatory Skin Diseases

Reticulohistiocytic granuloma

…mpanied, nearly invariably, by a mix of inflammatory cells, as shown here. Bibliography Bibliography for reticulohistiocytic granuloma Allen AC. Survey of pathologic studies of cutaneous diseases during World War II. Arch Dermatol Syphilol 1946;57…