Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…iosis lipoidica for mucin of granuloma annulare; the former is blue and amorphous, whereas the latter is blue and finely granular. Mucin is stained a brilliant aquamarine by colloidal iron, but degeneration of collagen is not stained by it at all. So…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…um, globi are invariable and can be discerned with facility in sections stained by hematoxylin and eosin as large macrophages whose abundant, pale, reticulated cytoplasm has a light blue-gray cast as a consequence of its housing innumerable lepra bac…

Histologic Diagnosis of Inflammatory Skin Diseases

Leishmaniasis

Leishmaniasis Synonyms Leishmaniosis Presentation stereotypical Age and sex Young adults of both sexes Distribution of lesions Localized in Oriental sore, widespread in the mucocutaneous and post-kala-azar types, and disseminated in the anergic cuta…

Dermatology Practical & Conceptual

Dermatoscopy: A multicolored lesion on the forehead

…of 25 x 26 mm (Figure 1). Dermatoscopic examination disclosed blue-gray globules, leaf-like structures and structureless areas (Figures 2, 3). Figure 1. Pigmented lesion on forehead. [Copyright: ©2014 Senel.] Figures 2, 3. Dermatoscopy: blue-g…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ibrin is not present in the wall of venules, as here, findings such as those pictured suffice for diagnosis of leukocytoclastic vasculitis. In short, the changes shown are specific for that condition. 10.58.2A: Perivascular and interstitial der…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

…egeneration and are dispatched from their site original to the skin surface, where they reside temporarily in a neutrophil-containing crust atop an ulcer. In sections stained by hematoxylin and eosin, degenerated bundles of collagen appear blue rathe…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…hes a diagnosis of pernio. Perniosis refers to a change in the skin that follows on a disturbance in blood vessels. It is manifested as discoloration from red to dark blue, succeeded by blisters and even ulceration in some patients. Chilblain lupus,…