Dermatology Practical & Conceptual

An atypical pigmented lesion on the nose

The patient A 56-year-old Caucasian woman, with skin phototype III, presented with an asymptomatic, slow-growing, gray-black plaque on her nose. The lesion had appeared almost 6 months prior, was 10 x 5 mm in size and presented with a paler, raised…

Dermatology Practical & Conceptual

An atypical pigmented lesion on the nose—Answer

Below find the answer and discussion to the quiz by Savoia et al. presented in the previous issue of Dermatology Practical & Conceptual (http://dx.doi.org/10.5826/dpc.0401a12). Diagnosis Pigmented cutaneous squamous cell carcinoma (PCSCC). Clini…

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Method for Surgery

Not only the lesion for biopsy but also the method of biopsy must be chosen deliberately. It is obvious that certain methods of biopsy should not be employed when an inflammatory disease is suspected clinically, for example, curettage and electrocau…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat

The subcutaneous fat, like the dermis, is derived embryologically from mesenchyme. Primitive mesenchymal cells give rise to fibrocytes and to adipocytes. An adipocyte synthesizes so much fat in its cytoplasm that the lipid displaces and flattens the…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…und all epithelial structures of adnexa, i.e., hair follicles, sebaceous units, apocrine units, and eccrine units. Moreover, the vasculature and Schwann cells of nerves also are surrounded by a basement membrane. Figure 1.70 Basement membrane zone…

Dermatology Practical & Conceptual

Protecting the patient is our protection

Optimization and securing of medical practices and procedures has always been very challenging in medicine. However, the real-life clinical settings continue to pose various hazards that may lead medical professionals to unintended mistakes. Patholo…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.45.1A: Vesicular dermatitis, intraepidermal, acantholytic + 10.45.1B: Suprabasal separation with acantholytic dyskeratotic cells throughout most of the thickness of the thickened epidermis = Hailey-Hailey disease Because when th…