Differential Diagnosis in Dermatopathology

Discussions

…of sebaceous hyperplasia may be misinterpreted clinically as a basal-cell carcinoma because both conditions have a slightly elevated border and a central dell. In basal-cell carcinoma, however, the depression in the center usually represents an erosi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…en planus-like keratosis often is misinterpreted clinically as basal-cell carcinoma, it sometimes, albeit uncommonly, is removed by complete excision, as was the case here. As a rule, the lesion is shaved off superficially. Note at scanning magnifica…

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…arsenical keratosis, all three being superficial squamous-cell carcinomas. Basal-cell carcinomas also develop in chronic radiodermatitis, as do melanomas and sarcomas (so-called radiation sarcomas). The changes just enumerated that develop in the de…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ollagen in the upper part of the dermis, of lymphocytes in the basal layer, and of elongated mounds of parakeratosis militate against that diagnosis. 10.80.2A: Perivascular dermatitis, slightly spongiotic + 10.80.2B: Lymphocytes in the basa…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…dibula dilated and plugged by orthokeratotic and parakeratotic cells in a manner similar to that in the epidermis Late All the findings in lesions developed fully, except mitotic figures are not present above the basal layer, and there is no pallor…

Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…lectron microscopy to consist of a single layer of endothelial cells that line a narrow lumen, those cells being surrounded by a layer of pericytes (Fig. 1.78). The endothelial cells and pericytes are enveloped by a basal lamina. In the descending ve…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo?

…n of the rete pegs and melanocytic hyperplasia confined to the basal cell layer.” Farmer ER, Hood AF. Melanocytic tumors. In: Farmer ER, Hood AF, eds. Pathology of the Skin. New York, NY: McGraw-Hill, 2000:1108. “Solar lentigo shows elo…

Differential Diagnosis in Dermatopathology

Discussions

…osis, a thickened epithelium, and an infiltrate of mononuclear cells. The white color (leuko-) in both leukokeratosis and leukoplakia results from abnormal production and maceration of cornified cells. But the essential character of the two condition…