Histologic Diagnosis of Inflammatory Skin Diseases

Images

…llagen in the upper part of the dermis, of lymphocytes in the basal layer, and of elongated mounds of parakeratosis militate against that diagnosis. 10.80.2A: Perivascular dermatitis, slightly spongiotic + 10.80.2B: Lymphocytes in the basal

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…ibula dilated and plugged by orthokeratotic and parakeratotic cells in a manner similar to that in the epidermis Late All the findings in lesions developed fully, except mitotic figures are not present above the basal layer, and there is no pallor…

Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…ectron microscopy to consist of a single layer of endothelial cells that line a narrow lumen, those cells being surrounded by a layer of pericytes (Fig. 1.78). The endothelial cells and pericytes are enveloped by a basal lamina. In the descending ven…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo?

…of the rete pegs and melanocytic hyperplasia confined to the basal cell layer.” Farmer ER, Hood AF. Melanocytic tumors. In: Farmer ER, Hood AF, eds. Pathology of the Skin. New York, NY: McGraw-Hill, 2000:1108. “Solar lentigo shows elon…

Differential Diagnosis in Dermatopathology

Guttate psoriasis vs. Guttate (dermatosis) parapsoriasis

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…acks of lamellae. When viewed by electron microscopy, laminar cells are noted to possess a basal lamina and, at the periphery of a corpuscle, to be separated from one another by collagen fibers, elastic fibers, and fibrillary intercellular material….

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…pathologic Early Tiny vacuoles in the cytoplasm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in e…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…80 percent of those patients had infiltrates of inflammatory cells in blisters. No laboratory technique had been capable of differentiating acquired epidermolysis bullosa from bullous pemphigoid until electron microscopy and immunoelectron microscop…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…vus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figure 5). Histopathology of the nodule showed a nodular melanoma with an invasion thickness of 4.5 mm (Figure 6). On t…