Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Fibromatoses?

…nge from those composed largely of dense collagen with sparse spindle cells to densely cellular tumor-appearing masses. Classification: Palmar, plantar and penile fibromatosis Desmoid (Aggressive fibromatosis)” Cotran RS, Kumar V, Robbins SL. T…

Differential Diagnosis in Dermatopathology

Pretibial myxedema vs. Scleromyxedema

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ion of collagen bundles by acid mucopolysaccharides 5. Mast cells increased markedly in regions mucinous 5. Mast cells increased slightly in loci mucinous 6. Fibrocytes increased slightly and scattered as solitary units in stroma, mucin-rich, mos…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…obular + 10.70.2B: Interwoven fascicles of plump oval and spindle-shaped fibrocytes in conjunction with fibrillary bundles of collagen, abundant mucin, scattered lymphocytes, and extravasated erythrocytes = Nodular fasciitis ┬áThis condition funda…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…throughout the dermis and an increased number of stellate and spindle-shaped fibrocytes in the upper part of it = Radiation dermatitis, chronic ┬áThe findings in longstanding lesions of radiation dermatitis differ from those of morphea by sclerosis be…

Histologic Diagnosis of Inflammatory Skin Diseases

Pigmented Lesions

…early in the course) in a mass in the reticular dermis, those cells appearing to be splayed between thickened bundles of collagen at the lateral margins. Melanin increased in amount in the epidermis. Hamartomas Collagenous nevus, papillary dermal…

Differential Diagnosis in Dermatopathology

Discussions

…innumerable dilated blood vessels lined by plump endothelial cells, some endothelial cells in mitosis, a mixed infiltrate of inflammatory cells, stroma that tends to be edematous and contain some mucin and large fibrocytes, a thinned epidermis with…

Differential Diagnosis in Dermatopathology

Discussions

In addition to possessing some cells with extraordinarily atypical nuclei, those referred to colloquially as “monster” cells, the two pathologic processes of very different nature that are the basis for this particular exercise in differ…