Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…lump fibrocytes that act in a manner comparable to mesenchymal cells of a follicular papilla in an embryo, those cells bring forth the entire infundibulo-apocrine-sebaceous-follicular unit. Low-grade fibrosarcoma consists of abnormal spindle cells ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.70.1A: Panniculitis, septal mostly + 10.70.1B: Fibrosing granulation tissue, abundant mucin, and scattered lymphocytes = Nodular fasciitis ┬áThe changes pictured are a response to external trauma akin to those in an early stage o…

Histologic Diagnosis of Inflammatory Skin Diseases

Pigmented Lesions

…507, 508, 509) An epidermis thickened by two populations of cells, namely, pigmented “basaloid” ones with scant cytoplasm that make up the bulk of the lesion and nearly non-pigmented “squamoid” cells with copious cytoplasm…

Differential Diagnosis in Dermatopathology

Discussions

In addition to possessing some cells with extraordinarily atypical nuclei, those referred to colloquially as “monster” cells, the two pathologic processes of very different nature that are the basis for this particular exercise in differ…

Differential Diagnosis in Dermatopathology

Discussions

…e innumerable dilated blood vessels lined by plump endothelial cells, some endothelial cells in mitosis, a mixed infiltrate of inflammatory cells, stroma that tends to be edematous and contain some mucin and large fibrocytes, a thinned epidermis with…

Differential Diagnosis in Dermatopathology

Discussions

…phocytes and eosinophils, possess vessels lined by endothelial cells that may be plump and contain abundant cytoplasm, display fibroplasia, exhibit many plasma cells, and spare epithelial and non-epithelial structures of adnexa. Despite these element…

Differential Diagnosis in Dermatopathology

Dermatofibroma with "monster" cells vs. Malignant fibrous histiocytoma

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Histologic Diagnosis of Inflammatory Skin Diseases

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.16.1A: Nodular dermatosis + 11.16.1B: Proliferation of small blood vessels enclosed partially by collarettes of epithelium = Pyogenic granuloma, early ┬áNote the large, muscle-containing “feeder” vessel at the base of…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Dermatofibrosarcoma protuberans

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….