Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ollagen in the upper part of the dermis, of lymphocytes in the basal layer, and of elongated mounds of parakeratosis militate against that diagnosis. 10.80.2A: Perivascular dermatitis, slightly spongiotic + 10.80.2B: Lymphocytes in the basa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mycosis Fungoides—Increasing in Incidence?

“Mycosis fungoides does appear to be increasing in frequency more rapidly than lymphoma in general.” Weinstock MA. Epidemiology of mycosis fungoides. Semin Dermatol 1994;13(3):154–59. “The incidence [of mycosis fungoides…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…s and Bowen’s disease, and both seborrheic keratosis and basal-cell carcinoma. Very rarely, that may be true for seborrheic dermatitis and psoriasis, but the collision is a happenstance, not an overlap as that word is applied in “overlap…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo?

…n of the rete pegs and melanocytic hyperplasia confined to the basal cell layer.” Farmer ER, Hood AF. Melanocytic tumors. In: Farmer ER, Hood AF, eds. Pathology of the Skin. New York, NY: McGraw-Hill, 2000:1108. “Solar lentigo shows elo…

Differential Diagnosis in Dermatopathology

Discussions

…osis, a thickened epithelium, and an infiltrate of mononuclear cells. The white color (leuko-) in both leukokeratosis and leukoplakia results from abnormal production and maceration of cornified cells. But the essential character of the two condition…

Differential Diagnosis in Dermatopathology

Guttate psoriasis vs. Guttate (dermatosis) parapsoriasis

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…microscopy 2. Demonstration of blister formation beneath the basal lamina, which remains on the epidermal side of the blister by electron microscopy 3. Deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectr…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…liam Montagna, Ph.D.) Unmyelinated axons surrounded by Schwann cells are arrayed in a branching and overlapping network. Many of the unmyelinated axons terminate near the dermoepidermal junction, where basal lamina of their Schwann cells make contact…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

Abstract Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculo…