Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…microscopy 2. Demonstration of blister formation beneath the basal lamina, which remains on the epidermal side of the blister by electron microscopy 3. Deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectr…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

Abstract Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculo…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…asm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epidermal basal cells at the sides of the blis…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…liam Montagna, Ph.D.) Unmyelinated axons surrounded by Schwann cells are arrayed in a branching and overlapping network. Many of the unmyelinated axons terminate near the dermoepidermal junction, where basal lamina of their Schwann cells make contact…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma 1. Strands, cords, and columns of neoplastic epithelial cells in the dermis 1. Cords and columns of neoplastic epithelial cells in the dermis; no strands as a rule 2. Differen…

Differential Diagnosis in Dermatopathology

Images

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

“Epidermoid cyst. Synonym: Sebaceous cyst, steatoma, epithelial cyst. Definition: A cyst containing keratin and its breakdown products, surrounded by an epidermoid wall.” Mackie RM. Epidermal skin tumors. In: Champion RH, Burton JL, Eb…