Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…pathologic Early Tiny vacuoles in the cytoplasm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in e…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

…vus showed elongation of rete ridges and hyperpigmentation of basal keratinocytes but no substantial proliferation of melanocytes (Figure 5). Histopathology of the nodule showed a nodular melanoma with an invasion thickness of 4.5 mm (Figure 6). On t…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…acks of lamellae. When viewed by electron microscopy, laminar cells are noted to possess a basal lamina and, at the periphery of a corpuscle, to be separated from one another by collagen fibers, elastic fibers, and fibrillary intercellular material….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…80 percent of those patients had infiltrates of inflammatory cells in blisters. No laboratory technique had been capable of differentiating acquired epidermolysis bullosa from bullous pemphigoid until electron microscopy and immunoelectron microscop…

Histologic Diagnosis of Inflammatory Skin Diseases

Dystrophic epidermolysis bullosa

…Vacuoles beneath the epidermis No infiltrate of inflammatory cells Fully developed Subepidermal blister Little or no infiltrate of inflammatory cells Late Fibroplasia in the upper part of the dermis Subepidermal clefts above the scar sometimes E…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…rmal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lami…

Differential Diagnosis in Dermatopathology

Images

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Metastatic carcinoma from a breast Morpheiform basal-cell carcinoma 1. Strands, cords, and columns of neoplastic epithelial cells in the dermis 1. Cords and columns of neoplastic epithelial cells in the dermis; no strands as a rule 2. Differen…

Differential Diagnosis in Dermatopathology

Erythroderma of psoriasis vs. Erythroderma of mycosis fungoides

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Epidermal Cyst and Epidermoid Cyst?

…an involuting follicle well advanced in catagen (exhibiting a basal layer, a pale spinous layer in which “spines” are seen with great difficulty, no granular zone, and compact orthokeratosis), and which is referred to by us as “foll…