Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…lectron microscopy to consist of a single layer of endothelial cells that line a narrow lumen, those cells being surrounded by a layer of pericytes (Fig. 1.78). The endothelial cells and pericytes are enveloped by a basal lamina. In the descending ve…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ollagen in the upper part of the dermis, of lymphocytes in the basal layer, and of elongated mounds of parakeratosis militate against that diagnosis. 10.80.2A: Perivascular dermatitis, slightly spongiotic + 10.80.2B: Lymphocytes in the basa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo?

…n of the rete pegs and melanocytic hyperplasia confined to the basal cell layer.” Farmer ER, Hood AF. Melanocytic tumors. In: Farmer ER, Hood AF, eds. Pathology of the Skin. New York, NY: McGraw-Hill, 2000:1108. “Solar lentigo shows elo…

Differential Diagnosis in Dermatopathology

Discussions

…osis, a thickened epithelium, and an infiltrate of mononuclear cells. The white color (leuko-) in both leukokeratosis and leukoplakia results from abnormal production and maceration of cornified cells. But the essential character of the two condition…

Differential Diagnosis in Dermatopathology

Guttate psoriasis vs. Guttate (dermatosis) parapsoriasis

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…microscopy 2. Demonstration of blister formation beneath the basal lamina, which remains on the epidermal side of the blister by electron microscopy 3. Deposition of IgG in the amorphous zone beneath the basal lamina, demonstrable by immunoelectr…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…liam Montagna, Ph.D.) Unmyelinated axons surrounded by Schwann cells are arrayed in a branching and overlapping network. Many of the unmyelinated axons terminate near the dermoepidermal junction, where basal lamina of their Schwann cells make contact…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…asm of epidermal basal cells and no infiltrate of inflammatory cells in the dermis Fully developed Dermal papillae preserved beneath what seems, at first blush, to be a subepidermal blister Vacuoles in epidermal basal cells at the sides of the blis…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

Abstract Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal and Epidermal Types of Erythema Multiforme?

…ermal edema resulting in intradermal bulla formation, with the basal lamina at the top of the blister. (b) ‘Target’ lesions showed primarily epidermal damage resulting in bulla formation at the dermal-epidermal junction with the basal lam…