Differential Diagnosis in Dermatopathology

Differential Diagnosis

Morphea, late stage Collagenous nevus 1. Epidermis normal or thinned with effacement of rete ridges 1. Epidermis normal or gently mammillated 2. Thick collagen bundles aligned parallel to the skin surface 2. Thick collagen bundles arranged obl…

Differential Diagnosis in Dermatopathology

Discussions

…ral findings histopathologic in common, among them mesenchymal cells with abundant pink cytoplasm scattered among bundles of collagen, multinucleate cells in sections of tissue of some specimens, deposits of mucin in company with an increased number…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…of collagen and no nuclear “dust” of inflammatory cells 3. Degeneration of collagen and nuclear “dust” of inflammatory cells in the center of palisades of histiocytes 4. Oval and spindle-shaped fibrocytes constitute the der…

Differential Diagnosis in Dermatopathology

Discussions

…residuum of a once dense infiltrate of lymphocytes and plasma cells may be present even at a late stage of morphea. No inflammatory cells are seen, however, in a collagenous nevus. Orientation of collagen bundles is crucial for distinguishing a late…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…on, but not acanthotic at the periphery of it 3. No nests of cells in the dermis 3. Nests of cells in the dermis 4. Stellate, oval, spindle-shaped, and round cells (fibrocytes and histiocytes); no polygonal cells 4. Polygonal cells (abnormal mela…