Histologic Diagnosis of Inflammatory Skin Diseases

Images

…11.16.2B: Proliferation of small vessels, edema, a mixed-cell infiltrate, and a thinned epidermis = Pyogenic granuloma, fully developed  At the base of the section is a large muscle-containing vessel that spiraled upward and from which sprang th…

Differential Diagnosis in Dermatopathology

Discussions

…innumerable dilated blood vessels lined by plump endothelial cells, some endothelial cells in mitosis, a mixed infiltrate of inflammatory cells, stroma that tends to be edematous and contain some mucin and large fibrocytes, a thinned epidermis with…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Dermatofibrosarcoma protuberans

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Differential Diagnosis in Dermatopathology

Discussions

…hocytes and eosinophils, possess vessels lined by endothelial cells that may be plump and contain abundant cytoplasm, display fibroplasia, exhibit many plasma cells, and spare epithelial and non-epithelial structures of adnexa. Despite these elements…

Differential Diagnosis in Dermatopathology

Pyogenic granuloma vs. Bacillary angiomatosis

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Differential Diagnosis in Dermatopathology

Angiolymphoid hyperplasia with eosinophilia vs. Kimura’s disease

A systemic disease, which manifests itself in the skin first as violaceous macules and patches that tend to progress to papules and plaques, and sometimes to nodules and tumors, all of which represent hyperplasia of endothelial cells….

Differential Diagnosis in Dermatopathology

Discussions

…residuum of a once dense infiltrate of lymphocytes and plasma cells may be present even at a late stage of morphea. No inflammatory cells are seen, however, in a collagenous nevus. Orientation of collagen bundles is crucial for distinguishing a late…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…n, but not acanthotic at the periphery of it 3. No nests of cells in the dermis 3. Nests of cells in the dermis 4. Stellate, oval, spindle-shaped, and round cells (fibrocytes and histiocytes); no polygonal cells 4. Polygonal cells (abnormal melan…

Differential Diagnosis in Dermatopathology

Discussions

…al findings histopathologic in common, among them mesenchymal cells with abundant pink cytoplasm scattered among bundles of collagen, multinucleate cells in sections of tissue of some specimens, deposits of mucin in company with an increased number o…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…nd fascicles of mesenchymal cells 2. Fascicles of mesenchymal cells common, but no whorls of them 3. Nuclei of mesenchymal cells not crowded 3. Nuclei of mesenchymal cells crowded 4. Nuclei relatively monomorphic, i.e., mostly plump oval and spin…