Histologic Diagnosis of Inflammatory Skin Diseases

Images

…uration of the dermoepidermal junction by lymphocytes, jagged acanthosis, wedge-shaped hypergranulosis, and compact orthokeratosis = Lichen planus, early Zones of wedge-shaped hypergranulosis are centered around acrosyringia and the upper part of inf…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…atosis, and in Darier’s disease all cornify abnormally. ACANTHOSIS [Gk. acantha (thorn) + -osis (condition)]: An increase in thickness of the epidermis consequent to an increase in thickness of the spinous (prickle, malpighiian) zone secondary…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…e of histiocytes, plasma cells, and lymphocytes with variable acanthosis = Syphilis, secondary + Hyphae in the stratum corneum = Dermatophytosis + Pseudohyphae in the stratum corneum = Candidiasis + Mitotic figures above the basal layer and dil…

Histologic Diagnosis of Inflammatory Skin Diseases

Persistent light reaction

…nd multinucleate fibrocytes in the thickened papillary dermis Acanthosis, sometimes unevenly psoriasiform Slight spongiosis in foci sometimes Slight compact orthokeratosis and, at times, parakeratosis Correlation clinicopathologic Papules result mos…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…acuolar alteration and individual necrotic keratocytes Jagged acanthosis and wedge-shaped hypergranulosis Cornified layer mostly basket-weave, but compact orthokeratosis especially above foci of hypergranulosis Fully developed Superficial perivascu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmatitis, spongiotic + 10.81.2B: Lymphocytes only, slight acanthosis, and subtle foci of parakeratosis = Pityriasis rosea, early ¬†Erythrocytes extravasated in the papillary dermis and in the epidermis, as shown, are findings expected in pityriasi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…eate, in conjunction with coarse bundles of collagen and with acanthosis = Dermatofibroma This process, inflammatory fundamentally, is characterized by lymphocytes around venules in the upper part of the subcutaneous fat and fibroplasia throughout th…

Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis rubra pilaris

…rse superficial perivascular infiltrate of lymphocytes Slight acanthosis Foci of parakeratosis alternate with orthokeratosis in both vertical and horizontal directions beneath the original cornified layer with its basket-weave configuration Fully de…