Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

…y also demonstrate histologic features resembling cutaneous T cell lymphoma (so called actinic reticuloid). Currently, this end-stage condition is termed chronic actinic dermatitis, and includes the conditions previously labeled photosensitive eczema…

Therapeutic Strategies in Dermatology

Lichen Planus: Key Points

…rarely of the skin, may be complicated by the development of squamous cell carcinoma. Lichen planus may be triggered by or found in association with exogenous factors, such as medications or contact allergens; a treatable cause should always be soug…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…t to maintain a high quality of life. Drug eruptions, chronic actinic dermatitis, and, rarely, allergic contact dermatitis can have histologic features very similar to CTCL. Even T-cell gene rearrangement studies may be positive. These conditions mus…

Therapeutic Strategies in Dermatology

Venous Stasis: Treatment

…tfalls A non-healing ulcer may be cutaneous carcinoma (basal cell, squamous cell, etc.) or an inflammatory ulcer (such as pyoderma gangrenosum). Biopsy non-healing ulcerations after three months of treatment or if there is concern for an alternative…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…