Search Results for: alpha-1 antitrypsin deficiency

Therapeutic Strategies in Dermatology

Lymphomatoid Papulosis: Overview

…twice daily to new lesions, followed by pulse therapy on weekends, may be effective and has minimal toxicity. Bexarotene gel 1% may be applied to early lesions as tolerated once or twice daily. This may prevent progression and speed healing….

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…e of progression of the HIV-associated KS. The following staging system may be used: Stage I: Localized cutaneous (fewer than 10 lesions, or one anatomic region); Stage II: Disseminated cutaneous (more than 10 lesions, or more than one anatomic…

Therapeutic Strategies in Dermatology

Raynaud’s Phenomenon/Disease: Overview

…ud’s phenomenon, drug treatment is beneficial. The calcium channel blockers amlodipine 2.5-10 mg once daily, nifedipine 10-30 mg 3 times daily, or diltiazem 30-60 mg four times daily will control symptoms in the majority of patients….

Therapeutic Strategies in Dermatology

Behçet Syndrome: Overview

…olute avoidance of pregnancy is required. Patients with severe or multisystem disease are treated with prednisone starting at 1 mg/kg/day plus at times a steroid sparing agent. Azathioprine, chlorambucil, cyclosporine, methotrexate, and alpha

Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

…agents (urea) are usually tried first. The efficacy of these agents are similar and the clinician may choose ammonium lactate 12% gel, lactic acid 6% lotion, or 40% urea in petrolatum with or without 5-10% lactic acid depending of the degree of…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…ed excision margins: European (Leiter U, et al. 2010) Melanoma in situ 0.5 cm 0.5 cm Breslow < 1 mm thickness 1 cm Breslow 1-2 mm 1-2 cm Breslow < 2 mm thickness 1 cm Breslow > 2 mm thickness 2 cm (at least) 2 cm Melanoma in situ should be…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…ve cutaneous disease. Trimethoprim/sulphamethoxazole 12-15 mg/kg/day for 1-3 months may be effective in children. Thalidomide 100 mg/day for 1 month, then 50 mg/day for 1-2 months. Isotretinoin 1.5 mg/kg/day for 6 or more months may induce a…

Therapeutic Strategies in Dermatology

Viral Exanthems: Treatment

…ric cases,hydroxyzine syrup (dosed at 1-2 mg/kg/day divided 3-4 times daily) or diphenhydramine elixir (6.25 mg for ages 2-5, 12.5-25 mg for ages 6-11, 25-50 mg for ages 12 and older) every 6 to 8 hours or at bedtime can be used. Tepid baths with…

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…ence of widespread candidiasis, involving mucosal and skin sites (especially the nails and nail folds), may suggest an immunodeficiency disorder, such as chronic mucocutaneous candidiasis. The differential diagnosis of candidiasis, especially in the…

Therapeutic Strategies in Dermatology

Porphyria Cutanea Tarda: Overview

…ith erythropoietin. Subsequent steps Phlebotomy is continued until clinical improvement occurs, keeping the hemoglobin in the 10- to 11-g range. Urine porphyrins fall with phlebotomy and may continue to fall for months after phlebotomy is…