Search Results for: alpha-1 antitrypsin deficiency

Therapeutic Strategies in Dermatology

Raynaud’s Phenomenon/Disease: Overview

…surface for years after the initial occurrence of Raynaud’s phenomenon. Therefore, work-ups need to be repeated at regular intervals. Certain drugs, such as ergotamines and alpha-blockers, can aggravate or precipitate Raynaud’s disease….

Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

…. Treatment Mild ichthyosis First Steps Emollients with added alpha-hydroxy acids (lactic acid), or hygroscopic agents (urea) are usually tried first. The efficacy of these agents are similar and the clinician may choose ammonium lactate 12% gel, lac…

Therapeutic Strategies in Dermatology

Behçet Syndrome: Overview

…is required. Patients with severe or multisystem disease are treated with prednisone starting at 1 mg/kg/day plus at times a steroid sparing agent. Azathioprine, chlorambucil, cyclosporine, methotrexate, and alpha interferon have all been used….

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…d methotrexate, vinblastine, 6-mercaptopurine, and etoposide. Alpha interferon in doses of up to 6 million units daily can be used in refractory disease. While cyclosporine in high doses 12 mg/kg/day leads to resolution of skin disease, relapses freq…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…h aggressive features such as ulceration or mitotic index >1 per mm2) should be considered for sentinel lymph node biopsy (Balch CM, et al. AJCC, 2009). Adjuvant treatment after surgery with interferon-alpha-2b has proven a disease free survival b…

Therapeutic Strategies in Dermatology

Viral Exanthems: Treatment

…us lesions and/or pruritus: Antihistamines (e.g., hydroxyzine 10-25 mg t.i.d. [such as Atarax], diphenhydramine 25-50 mg t.i.d. [such as Benadryl], or chlorpheniramine 4-16 mg/day) can be used to alleviate pruritus. For pediatric cases, hydroxyzine s…

Therapeutic Strategies in Dermatology

Angular Cheilitis: Key Points

…e ongoing exposure to moisture as part of the treatment plan. Other medical considerations in the differential diagnosis of angular cheilitis include: nutritional deficiency, inflammatory bowel disease, allergic contact dermatitis, and medications….

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…se pityriasis rosea, allergic or irritant contact dermatitis, deficiency dermatitis, Hailey-Hailey or Darier’s disease, axillary granular parakeratosis, Kawasaki syndrome, as well as cutaneous malignancies such as squamous cell carcinoma, extra…

Therapeutic Strategies in Dermatology

Porphyria Cutanea Tarda: Overview

…disorders in the remaining 80% of cases. PCT is related to a deficiency of the enzyme uroporphyrinogen decarboxylase. Treatment First steps Stop exacerbating drugs (estrogens, OCPs, iron). Counsel the patient to stop all alcohol ingestion. Inform th…

Therapeutic Strategies in Dermatology

Linear IgA Dermatosis: Overview

…Linear IgA dermatosis is initially treated with oral dapsone 100 mg/day. Expect a clinical response within 5-10 days. b. If blistering is not controlled, increase dapsone every 1-2 weeks in 25-mg increments until the desired clinical response is obt…