Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…g system may be used: Stage I: Localized cutaneous (fewer than 10 lesions, or one anatomic region); Stage II: Disseminated cutaneous (more than 10 lesions, or more than one anatomic area); Stage III: Visceral only; Stage IV: Cutaneous and visceral or…

Therapeutic Strategies in Dermatology

Raynaud’s Phenomenon/Disease: Overview

Overview Peripheral vasospasm can occur as an isolated disease entity (Raynaud’s disease) or in association with another disease process, such as scleroderma and other rheumatic diseases (Raynaud’s phenomenon). Typically, the digits are…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

…unresponsive cutaneous disease. Trimethoprim/sulphamethoxazole 12-15 mg/kg/day for 1-3 months may be effective in children. Thalidomide 100 mg/day for 1 month, then 50 mg/day for 1-2 months. Isotretinoin 1.5 mg/kg/day for 6 or more months may induce…

Therapeutic Strategies in Dermatology

Ichthyoses/Disorders of Cornification: Overview

…e. Treatment Mild ichthyosis First Steps Emollients with added alpha-hydroxy acids (lactic acid), or hygroscopic agents (urea) are usually tried first. The efficacy of these agents are similar and the clinician may choose ammonium lactate 12% gel, la…

Therapeutic Strategies in Dermatology

Behçet Syndrome: Overview

Overview BehÇet syndrome is a disorder of unknown cause characterized by oral and genital mucous membrane ulceration, erythema nodosum-like lesions, uveitis, and numerous other vascular, rheumatological, and gastrointestinal complications. Because t…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…, et al. 2010) Melanoma in situ 0.5 cm 0.5 cm Breslow < 1 mm thickness 1 cm Breslow 1-2 mm 1-2 cm Breslow < 2 mm thickness 1 cm Breslow > 2 mm thickness 2 cm (at least) 2 cm The appropriate margin for excision is highly contr…

Therapeutic Strategies in Dermatology

Porphyria Cutanea Tarda: Overview

…frequent phlebotomies. Alternative steps Low-dose chlorquine 125 mg 2 times/week is quite effective. Check the LFTs, then give a test dose of chlorquine 125 mg, and recheck the LFTs before instituting therapy. Hydroxychlorquine 250 mg twice weekly…

Therapeutic Strategies in Dermatology

Angular Cheilitis: Key Points

Key Points Angular cheilitis, also known as perlÈche, results from maceration, inflammation, and an overgrowth of microorganisms, especially Candida albicans, at the corners of the mouth. Moisture and maceration stemming from chronic exposure to s…

Therapeutic Strategies in Dermatology

Linear IgA Dermatosis: Overview

…. Linear IgA dermatosis is initially treated with oral dapsone 100 mg/day. Expect a clinical response within 5-10 days. b. If blistering is not controlled, increase dapsone every 1-2 weeks in 25-mg increments until the desired clinical response is ob…

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

Key Points Candidiasis typically affects mucosal sites and moist and/or occluded areas of skin: groin, axilla, inframammary, infra-abdominal pannus, glans penis (in uncircumcised males), and orogenital mucosal sites. Predisposing factors include o…