Dermatology Practical & Conceptual

Widespread pruritic papules on the trunk and extremities

…©2014 Sezer et al.] Answer and explanation Generalized lichen amyloidosis. On histopathological examination, epidermal changes including marked hyperkeratosis, hypergranulosis, and irregular acanthosis were observed. An additional finding was the pre…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen simplex chronicus/Prurigo nodularis/Picker’s nodule/Erosions/Ulcers

…y to epidermal keratocytes already has occurred, e.g., lichen amyloidosis. One hypothesis holds that globules of amyloid in macular and papular (lichenoid) amyloidosis represent necrotic keratocytes that have formed secondary to excoriation and that…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…ot a substance specific unto itself, unlike the situation for amyloid, mucin, and urate. Error: Hypereosinophilic syndrome is authentic. Reason: What is termed “hypereosinophilic syndrome” is devoid of specificity; it is a “wastebas…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

…sions of EPP must be differentiated from sclerodermas, lichen amyloidosis, and lipoid proteinosis. Histopathologically, the biopsy showed a normal epidermis. The papillary dermis demonstrated extensive, circumscribed deposits of eosinophilic, homogen…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…papular mucinosis      Perforating myxoid cyst Elimination of Amyloid      Perforating cutaneous amyloidosis” Shames BS, Fretzin D. Disorders of collagen, elastin, and ground substance. In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd ed. Ph…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…inable substances, such as fibrin, erythrocytes, keratocytes, amyloid, and colloid. “ID” [Gk. -ides (son or daughter, descendent)]: A suffix employed by dermatologists in such an inconsistent way that no unifying theme can be identified f…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ntact dermatitis, and dermatophytosis, deposits as in macular amyloidosis, i.e., lichen amyloidosis, and neoplastic diseases like mycosis fungoides. Figure 3.10 Coarse collagen bundles in vertical streaks. COMEDO [L. comedo (glutton)]: A dilated i…