Histologic Diagnosis of Inflammatory Skin Diseases

Lichen simplex chronicus/Prurigo nodularis/Picker’s nodule/Erosions/Ulcers

…ry to epidermal keratocytes already has occurred, e.g., lichen amyloidosis. One hypothesis holds that globules of amyloid in macular and papular (lichenoid) amyloidosis represent necrotic keratocytes that have formed secondary to excoriation and that…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…papular mucinosis      Perforating myxoid cyst Elimination of Amyloid      Perforating cutaneous amyloidosis” Shames BS, Fretzin D. Disorders of collagen, elastin, and ground substance. In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd ed. P…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

…res mentioned above the differential diagnoses considered were amyloidosis, erythropoietic protoporphyria, and lipoid proteinosis. Congo red did not stain the deposits, making amyloidosis unlikely. In lipoid proteinosis, the deposits usually surround…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

APOPTOSIS [Gk. apo- (away from) + ptosis (a falling)]: Reputed to be a specific type of cell death in which dead cells are said to undergo fragmentation by implosion with subsequent phagocytosis of nuclear debris (Fig. 3.40). The process is claimed…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ontact dermatitis, and dermatophytosis, deposits as in macular amyloidosis, i.e., lichen amyloidosis, and neoplastic diseases like mycosis fungoides. Figure 3.10 Coarse collagen bundles in vertical streaks. COMEDO [L. comedo (glutton)]: A dilated…

Differential Diagnosis in Dermatopathology


Trichoblastoma is the name generic for all benign neoplasms composed of trichoblasts and trichoblastic carcinoma is the term generic for all malignant neoplasms made up of trichoblasts. A synonym for trichoblastic carcinoma is basal-cell carcinoma….