Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

Malignant neoplasms of B-lymphocytes especially that present themselves usually as papules, nodules, and tumors, sometimes solitary but at other times numerous, and often in clusters on any anatomic site. When “primary,” B-cell lymphomas o…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…tis can have histologic features very similar to CTCL. Even T-cell gene rearrangement studies may be positive. These conditions must be excluded before treating the patient for CTCL. Stage IA-patches or plaques <10% body surface area Stage IB-pat…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Alopecia: Key Points

…icture or a specific histopathologic pattern (the distinction between neutrophilic versus lymphocytic scarring alopecia informs treatment directed at a particular immune cell-i.e., dapsone for neutrophils or mycophenolate mofetil for lymphocytes). If…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Clinical Cases

…evaluation Minimal interval improvement The patient’s bone marrow biopsy reveals acute myeloid leukemia; he is admitted to the hospital and started on induction chemotherapy; in the hospital, his wound care is continued As his leukemia goes i…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Treatment

…prompt an evaluation for systemic diseases, particularly chilblains lupus erythematosus or chronic myelomonocytic leukemia. The presence of thromboses should prompt consideration of thrombotic disorders including cryoglobulinemia or anti-phospholipi…

Histologic Diagnosis of Inflammatory Skin Diseases

Adult T-cell leukemia/Lymphoma

Adult T-cell leukemia/Lymphoma Presentation stereotypical Age and sex No predilection for sex. Middle-aged individuals from southern Japan and Caribbean Islands. Distribution of lesions Widespread Arrangement Scattered discrete lesions Individual le…