Search Results for: b-cell lymphocytic leukemia

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

Malignant neoplasms of B-lymphocytes especially that present themselves usually as papules, nodules, and tumors, sometimes solitary but at other times numerous, and often in clusters on any anatomic site. When “primary,” Bcell lymphomas o…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…tis can have histologic features very similar to CTCL. Even T-cell gene rearrangement studies may be positive. These conditions must be excluded before treating the patient for CTCL. Stage IA-patches or plaques <10% body surface area Stage IB-patc…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Alopecia: Key Points

…icture or a specific histopathologic pattern (the distinction between neutrophilic versus lymphocytic scarring alopecia informs treatment directed at a particular immune cell-i.e., dapsone for neutrophils or mycophenolate mofetil for lymphocytes). If…

Therapeutic Strategies in Dermatology

Pyoderma Gangrenosum: Clinical Cases

…p evaluation Minimal interval improvement The patient’s bone marrow biopsy reveals acute myeloid leukemia; he is admitted to the hospital and started on induction chemotherapy; in the hospital, his wound care is continued As his leukemia goes i…

Therapeutic Strategies in Dermatology

Pernio/Chilblains: Treatment

…prompt an evaluation for systemic diseases, particularly chilblains lupus erythematosus or chronic myelomonocytic leukemia. The presence of thromboses should prompt consideration of thrombotic disorders including cryoglobulinemia or anti-phospholipi…

Histologic Diagnosis of Inflammatory Skin Diseases

Adult T-cell leukemia/Lymphoma

Adult T-cell leukemia/Lymphoma Presentation stereotypical Age and sex No predilection for sex. Middle-aged individuals from southern Japan and Caribbean Islands. Distribution of lesions Widespread Arrangement Scattered discrete lesions Individual le…