A Clinical Atlas of 101 Common Skin Diseases

Arthropod Assaults

Papules, nodules, vesicles, and sometimes bullae that develop in response to “bites” of arthropods, among the most common offenders being mosquitoes, bedbugs, and mites of scabies….

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…er of a blister in infection by herpesvirus: intraspinous with ballooning. The blister induced by herpesvirus begins in the spinous zone with marked ballooning of keratocytes. Figure 5.249 A&B. The usual location and character of a blister in…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…dermatitis, lichenoid, superficial and deep. Figure 5.20 A. Ballooning dermatitis, superficial. B. Ballooning dermatitis, superficial and deep. Figure 5.21 A. Spongiotic dermatitis, superficial. B. Spongiotic dermatitis, superficial and deep….

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…me, fixed drug eruption, and Mucha-Habermann disease. The term ballooning, if unmodified, is enigmatic because ballooning refers also to the appearance of swollen cytoplasm in types of cells other than keratocytes, such as ballooned melanocytes of ne…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.32.1A: Perivascular dermatitis, interface, vacuolar + 10.32.1B: Predominance of lymphocytes, ballooned and individual necrotic keratocytes, and slight spongiosis = Erythema multiforme The normal cornified layer with its basket-w…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

…ascular infiltrate of lymphocytes and by slight spongiosis and ballooning of spinous keratocytes. As lesions evolve to resemble a target, spongiosis and ballooning become more prominent, the latter eventuating in reticular alteration and intraepiderm…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…idermal clefts and subepidermal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue Intraepidermal and subepidermal vesiculation may occur together Lymphocytes in ass…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…eosinophils. Discoid lupus erythematosus lacks spongiosis and ballooning, as well as an infiltrate with a wedge shape. In time, the epidermal basement membrane thickens. Eruptive psoriasis is devoid of interface changes, necrotic keratocytes, and ba…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…to become subepidermal came into being by virtue of extensive ballooning and spongiosis. Spongiosis is dominant in the lower part of the epidermis and ballooning in the mid and upper parts, in the latter being so severe that necrosis of keratocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…um, which is a consequence of serum in zones of spongiosis and ballooning ascending the epidermal spinous zone. Differential diagnosis histopathologic Phototoxic dermatitis is characterized by more ballooning of keratocytes, more diffuse distribution…