Search Results for: ballooning

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…ucha-Habermann disease. That finding, which is most prominent in the upper half of the viable epidermis, is a consequence of ballooning, which, on occasion, eventuates in intraepidermal vesiculation. Almost always, the ballooning is accompanied by…

Histologic Diagnosis of Inflammatory Skin Diseases

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…d assault This particular intraepidermal blister that ruptured to become subepidermal came into being by virtue of extensive ballooning and spongiosis. Spongiosis is dominant in the lower part of the epidermis and ballooning in the mid and upper…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…in a blister that began within the epidermis = Blister secondary to effects of electric current, e.g., electrodesiccation + Ballooning intraepidermal vesiculation with epidermal necrosis = Second-degree burn + Eosinophils and sometimes neutrophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…Scale-crusts consist of mounds of parakeratosis that house serum, which is a consequence of serum in zones of spongiosis and ballooning ascending the epidermal spinous zone. Differential diagnosis histopathologic Phototoxic dermatitis is…

Histologic Diagnosis of Inflammatory Skin Diseases

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…manifestation referred to as pityriasis lichenoides et varioliformis acuta, which gallops. In the chronica type, there is no ballooning, intraepidermal vesiculation, or neutrophils in mounds of parakeratosis; in fact, spongiosis in slight and the…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

…epidermis beneath a new subepidermal blister whose roof is necrotic Correlation clinicopathologic Tense blisters result from ballooning vesiculation, the gray roof of a blister from confluent necrosis of the epidermis, and the red rim from dilation…

Differential Diagnosis in Dermatopathology

Photoallergic dermatitis vs. Phototoxic dermatitis

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema multiforme

…lymphocytes even may qualify as being lichenoid. When tense vesicles and bullae are biopsied, they may exhibit well-defined ballooning of spinous keratocytes in association with numerous individual necrotic keratocytes. In time, ballooning

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ules, in septic vasculitis thrombi are present in lumen of them. That occlusion results in infarction with subsequent severe ballooning, intraepidermal vesiculation, and epidermal necrosis. The changes pictured here are those of gonococcemia….