Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

Principles of Management of Melanoma Prognosis is largely determined by histologic features of the primary melanoma (depth of invasion and/or the degree to which the tumor has invaded the skin, as well as ulceration and mitotic index). The major ind…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Key Points

Key Points Erythema multiforme (EM) is a clinical syndrome marked by either target lesions and/or mucosal erosions. It may be idiopathic or seen in association with infections or medications. EM has been reported in association with herpes simplex…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blue Nevus?

…he epidermis and the dermis. Our cumbersome definition of blue nevus fails, like all others, have failed and are doomed to fail, because it presumes, incorrectly, that blue nevus is a single process pathologic in which there are variations aplenty on…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus?

…ed, nevus pertains to a birthmark, i.e., a hamartoma. The word nevus in dermatology, however, is not used simply as a synonym for birthmark. It also is applied to a particular acquired proliferation of melanocytes known as a melanocytic nevus, e.g.,…

Dermatology Practical & Conceptual

The so-called dysplastic nevus is not dysplastic at all

…lly, clinically and molecularly, that the so-called dysplastic nevus is a type of melanocytic nevus and should be managed like other types of melanocytic nevi [1,2]. This reinforces the notion set forth by the late Bernie Ackerman, who asserted more…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Malignant Spitz Nevus?

…amartomas, whereas acquired melanocytic nevi, such as those of Clark, Spitz, and Reed, are benign neoplasms), and they, of course, do not metastasize. Some melanomas begin in association with a preexisting nevus, especially superficial and “dee…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Normal, Typical, Ordinary, Banal, and Common Nevus?

…roposed and never will be. To recognize a “normal” nevus, a standard must exist for identifying an “abnormal nevus.” There is none, and neither is there an agreed-on measure by which to judge a “typical” versus an…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Differential Diagnosis in Dermatopathology

Verrucous seborrheic keratosis vs. Verrucous epidermal nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…