Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

…y Paget’s is almost always associated with an underlying carcinoma. The data on extramammary Paget’s are less clear, but between 25% and 50% have an associated carcinoma. A careful lymph node evaluation is essential. Immunoperoxidase mark…

Therapeutic Strategies in Dermatology

Warts: Treatment

…cal, flat, and pigmented condylomata may suggest the diagnosis of bowenoid papulosis. A biopsy should be performed. This is often associated with HPV 16 or 18, and histologically may show features of squamous cell carcinoma in situ. Total eradication…

Therapeutic Strategies in Dermatology

Lichen Planus: Key Points

…emic immunosuppression should be considered. Generalized forms often require systemic treatment, such as immunosuppression or phototherapy. Specific variants, such as erosive disease, require additional monitoring for evolution of squamous cell carci…

Therapeutic Strategies in Dermatology

Venous Stasis: Treatment

…pain control. Pitfalls A non-healing ulcer may be cutaneous carcinoma (basal cell, squamous cell, etc.) or an inflammatory ulcer (such as pyoderma gangrenosum). Biopsy non-healing ulcerations after three months of treatment or if there is concern…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

…lly noted at about 3 weeks. If this does not reduce the number of mast cells sufficiently, try intralesional triamcinolone 5 mg/cc to the lesion. In an occasional symptomatic case, excision of the lesion may be appropriate. If the child has symptoms…

Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

…s with ulcerative disease must be followed for the development of oral or genital squamous cell carcinoma. Optimal oral hygiene is an important adjunctive intervention in the management of oral lichen planus. Furthermore, eliminate potential sources…