Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.23.11B: Focus of epidermal necrosis above a subepidermal cleft = Changes secondary to scratching Sharp fingernails applied with fury to the skin produce the findings shown here, namely, clefts between necrotic epidermis and dermis. The alterati…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Keratosis Lichenoides Chronica?

…cal necrosis of the epidermis in conjunction with a suprabasal cleft. Below the cleft, some of the blood vessels were said to exhibit necrosis of the wall and occlusion of the lumen. Wise and Rein stated that lichen ruber moniliformis was unrelated t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.11.1A: Perivascular dermatosis, lichenoid + 11.11.1B: Lymphocytes, many necrotic keratocytes and a subepidermal cleft = Lichen planus-like keratosis, early ¬†Because lichen planus-like keratosis often is misinterpreted clinically…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…cuoles become confluent, and, as a consequence, a subepidermal cleft comes into being. A cleft is an artifact, a space. When, however, serum finds its way into such a subepidermal space, a subepidermal blister results, and that happens episodically a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.42.1A: Perivascular dermatitis, interface, vacuolar + 10.42.1B: Lymphocytes along the dermoepidermal junction, slight spongiosis, and necrotic keratocytes in a thin epidermis = Graft-versus-host disease Sometimes it is difficult…

Dermatology Practical & Conceptual

Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection

Abstract Background: Multinucleated giant cells in the epidermis can either be epithelial or histiocytic. Epithelial multinucleated giant cells are most often associated with herpes virus infections. Purpose: To review the histologic differential di…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…both aligned parallel to the skin surface, and a subepidermal cleft = Scar, fully developed ¬†A subepidermal cleft above a scar, unlike a blister that sometimes comes into being there, houses no serum. 10.96.6A: Fibrosing dermatitis + 10.96…

Dermatology Practical & Conceptual

Dermatoscopy of folliculosebaceous cystic hamartoma

Abstract A 29-year-old Japanese man presented to our institution with a nodule on his nose that had increased in size since childhood. Physical examination indicated the presence of an elastic, firm, pedunculated red nodule measuring 15 mm in size….

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…ymphocytes around venules of the superficial plexus Suprabasal clefts in discrete foci in the epidermis Above each cleft, acantholytic, dyskeratotic cells in the spinous and granular zones; some parakeratotic cells also acantholytic Epidermis, includ…