Histologic Diagnosis of Inflammatory Skin Diseases

Images

…10.23.11B: Focus of epidermal necrosis above a subepidermal cleft = Changes secondary to scratching Sharp fingernails applied with fury to the skin produce the findings shown here, namely, clefts between necrotic epidermis and dermis. The alterati…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.11.1A: Perivascular dermatosis, lichenoid + 11.11.1B: Lymphocytes, many necrotic keratocytes and a subepidermal cleft = Lichen planus-like keratosis, earlyBecause lichen planus-like keratosis often is misinterpreted…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Keratosis Lichenoides Chronica?

…cal necrosis of the epidermis in conjunction with a suprabasal cleft. Below the cleft, some of the blood vessels were said to exhibit necrosis of the wall and occlusion of the lumen. Wise and Rein stated that lichen ruber moniliformis was unrelated t…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…cuoles become confluent, and, as a consequence, a subepidermal cleft comes into being. A cleft is an artifact, a space. When, however, serum finds its way into such a subepidermal space, a subepidermal blister results, and that happens episodically a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…both aligned parallel to the skin surface, and a subepidermal cleft = Scar, fully developed  A subepidermal cleft above a scar, unlike a blister that sometimes comes into being there, houses no serum. 10.96.6A: Fibrosing dermatitis + 10.96…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.42.1A: Perivascular dermatitis, interface, vacuolar + 10.42.1B: Lymphocytes along the dermoepidermal junction, slight spongiosis, and necrotic keratocytes in a thin epidermis = Graft-versus-host disease Sometimes it is difficult…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…ymphocytes around venules of the superficial plexus Suprabasal clefts in discrete foci in the epidermis Above each cleft, acantholytic, dyskeratotic cells in the spinous and granular zones; some parakeratotic cells also acantholytic Epidermis, includ…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

Langerhans’ cells, named for Paul Langerhans who, while a medical student in Berlin in 1868, was the first to describe them, are dendritic cells that reside just above the middle of the spinous zone of the epidermis. They make their appearance…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…