Search Results for: collagen

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…lupus erythematosus are autoimmune bullous disorders, with tissue-bound and circulating autoantibodies reactive with the noncollagenous NCI domain of type VII collagen (C-VII). Here, we describe a novel acquired bullous dermatosis with…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…he greatest violence to fundamental concepts of general pathology in this regard is definition of necrobiosis as necrosis of collagen, rather than as degeneration of that fibrous protein. Collagen is a fiber and, unlike the fibrocytes that produce…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…atosis, cornoid lamellation, pale-cell acanthosis, and epithelial mucinosis, and to patterns of non-epithelium like keloidal collagen. Each of those patterns are met with in a variety of circumstances, e.g., keloidal collagen in a fully developed…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

…mis. This unusual response to minor trauma may indicate either an inherited or an acquired biochemical abnormality of dermal collagen.” Shames BS, Fretzin D. Disorders of collagen, elastin, and ground substance. In: Moschella SL, Hurley HJ,…

Differential Diagnosis in Dermatopathology

Keloid vs. Hypertrophic scar

…at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nules, histiocytes, some of them multinucleate, in palisaded and interstitial array in the reticular dermis, degeneration of collagen, and ribbon-like bundles of collagen, as well as sclerosis, in widened septa of the subcutaneous fat + 10.67.12C +…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…c infiltrate is scant, collagen bundles are thickened greatly, and the number of fibrocytes in company with those bundles of collagen is decreased. Abundant mucin is present in spaces between bundles of collagen. 10.97.8A: Perivascular and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…f collagen accompanied by plump fibrocytes, both of them in haphazard array = Keloid In the evolution of a keloid, the thick collagen bundles shown follow on formation of fibrillary collagen bundles. In an early stage of a keloid, there are no thick…