Search Results for: collagen

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…lupus erythematosus are autoimmune bullous disorders, with tissue-bound and circulating autoantibodies reactive with the noncollagenous NCI domain of type VII collagen (C-VII). Here, we describe a novel acquired bullous dermatosis with…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…he greatest violence to fundamental concepts of general pathology in this regard is definition of necrobiosis as necrosis of collagen, rather than as degeneration of that fibrous protein. Collagen is a fiber and, unlike the fibrocytes that produce…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

…mis. This unusual response to minor trauma may indicate either an inherited or an acquired biochemical abnormality of dermal collagen.” Shames BS, Fretzin D. Disorders of collagen, elastin, and ground substance. In: Moschella SL, Hurley HJ,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…atosis, cornoid lamellation, pale-cell acanthosis, and epithelial mucinosis, and to patterns of non-epithelium like keloidal collagen. Each of those patterns are met with in a variety of circumstances, e.g., keloidal collagen in a fully developed…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nules, histiocytes, some of them multinucleate, in palisaded and interstitial array in the reticular dermis, degeneration of collagen, and ribbon-like bundles of collagen, as well as sclerosis, in widened septa of the subcutaneous fat + 10.67.12C +…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…c infiltrate is scant, collagen bundles are thickened greatly, and the number of fibrocytes in company with those bundles of collagen is decreased. Abundant mucin is present in spaces between bundles of collagen. 10.97.8A: Perivascular and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…f collagen accompanied by plump fibrocytes, both of them in haphazard array = Keloid In the evolution of a keloid, the thick collagen bundles shown follow on formation of fibrillary collagen bundles. In an early stage of a keloid, there are no thick…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…1997;38(4):394-406. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen related peptides. Proc Natl Acad Sci U S A 1978;75:871-875. Schepers C, Ackerman AB. Dermal…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…efined in a repeatable, let alone comprehensible, way. Some authors equate “necrobiosis” with “necrosis of collagen,” but collagen is a fiber, not a cell, and, therefore, cannot undergo necrosis. We eschew the term…