Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

“myxoma (milk – s ? m?) [myxo – + G. -oma, tumor]. A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primiti…

Differential Diagnosis in Dermatopathology

Discussions

Lichen planus-like keratosis may be confused easily with lichen planus histopathologically, especially in sections from a specimen taken by punch technique. Ostensibly, both are superficial perivascular dermatitides with lichenoid infiltrates made u…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Lichen planus Lichenoid secondary syphilis 1. No parakeratosis 1. Parakeratosis often 2. Acanthosis with a jagged base usually 2. Acanthosis psoriasiform usually; base rarely jagged 3. No pallor in the upper half of the epidermis 3. Pallor s…

Differential Diagnosis in Dermatopathology

Discussions

The effects of products of dense, often bandlike infiltrates of lymphocytes can drive both lichen planus-like keratosis and primary cutaneous melanoma into regression, i.e., involution (as they can the type of melanocytic nevus picturesquely termed…