Therapeutic Strategies in Dermatology

Actinic Keratosis (a.k.a. Solar Keratosis): Clinical Cases

…w lesions on the dorsal hands She reports increasing scale and crusting of the lesions, noting that the crusting sloughs intermittently (but then recurs) No prior history of skin cancer History of extensive sun exposure during her youth and early adu…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…n of corticosteroids systemically or by application topically. CRUST [L. crusta (crust)]: A collection of serum that contains white blood cells, red blood cells, or both (Fig. 3.12). The honey-colored crusts of impetigo consist of serum and leukocyte…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.98.1A: Perivascular dermatitis, and infundibulitis, spongiotic + 10.98.1B: Predominance of lymphocytes and scale-crusts at lips of infundibular ostia = Seborrheic dermatitis ┬áMounds of scale-crust at lips of infundibular ostia a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.23.1A: Perivascular dermatitis, psoriasiform + 10.23.1B: Orthokeratosis, hypergranulosis, acanthosis, proliferation of infundibular and eccrine ductal keratocytes, and coarse bundles of collagen in vertical streaks = Lichen simp…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…Denominators in common: Discrete pink papules, erosions, and crusts. Features differentiating: Insect “bites” differ clinically from Grover’s disease by the presence often of papulovesicles and vesicles, and of hemorrhagic crusts….

Histologic Diagnosis of Inflammatory Skin Diseases

Reactive perforating collagenosis

…ching repeatedly. Lymphomatoid papulosis may present itself as crusted nodules, but lesions often are accompanied by papules that are not crusted and tend to be agminated. Findings histopathologic Fully developed Infiltrate composed mostly of neutr…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.44.1A: Perivascular dermatitis, sparse + 10.44.1B: A suprabasal cleft, acanthotic dyskeratotic cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis iden…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.66.1A: Perivascular dermatitis, interface, vacuolar + 10.66.1B: Lymphocytes along the dermoepidermal junction and in the spinous zone, and ballooned and necrotic keratocytes = Mucha-Habermann disease, acute That this lesion is r…