Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

An inflammatory process that develops secondary to trauma, usually in the form of a penetrating injury or rupture of a follicle, and that proceeds through stages of granulation tissue with numerous extravasated erythrocytes, granulomatous inflammati…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rous extravasated erythrocytes, siderophages, and fibrocytes = Dermatofibroma An important finding for diagnosis of a dermatofibroma such as this one is seen at the periphery of the lesion, namely, thickened bundles of collagen that seem to be envelo…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…ed inexorably by fibroplasia in the form of a scar, keloid, or dermatofibroma, fibrosing inflammations all. Scars (Fig. 5.366 A&B), keloids (Fig. 5.367 A&B), and dermatofibromas (Fig. 5.368 A&B) differ from one another clinically, histopa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…as like that which appeared in the center of some conventional dermatofibromas, which prompted them to propose that some sclerotic fibromas could represent older “degenerated” dermatofibromas. They believed, nonetheless, that some sclerot…

Differential Diagnosis in Dermatopathology

Discussions

…in this setting refers to one manifestation histopathologic of dermatofibroma and malignant fibrous histiocytoma, and but one of several findings that the two dissimilar processes have in common. In addition to “foam cells,” dermatofibrom…

Differential Diagnosis in Dermatopathology

Discussions

…rocytes and histiocytes are expected in any evolving lesion of dermatofibroma. In contrast with dermatofibroma with “monster” cells, malignant fibrous histiocytoma is a sarcoma characterized not only by mononuclear and multinucleate cells…

Histologic Diagnosis of Inflammatory Skin Diseases

A malignant nonepithelial neoplasm (a sarcoma) presumably of perineural fibrocytes that presents itself usually on the trunk, but sometimes elsewhere, such as the extremities, face, and scalp. A papule of it tends to become a plaque, a nodule, a tum…

Histologic Diagnosis of Inflammatory Skin Diseases

Nodular fasciitis

…fibroplasia. Although nodular fasciitis bears similarities to dermatofibroma, scar, and keloid, each an example of fibrosing inflammation, it differs from all three, least from dermatofibroma. Like dermatofibroma, mesenchymal cells of nodular fascii…