Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e, is seen only in classic discoid lupus erythematosus and in dermatomyositis. 10.63.7A: Perivascular dermatitis, interface, vacuolar and peri-infundibulitis/perifolliculitis + 10.63.7B: Lymphocytes, telangiectases, mucin in the upper part…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…s example of a vacuolar type of interface dermatitis, namely, dermatomyositis, necrotic keratocytes are disposed as solitary units and in tiny clusters, especially in the lower part of the epidermis. Changes in the epidermis such as these also may be…

Differential Diagnosis in Dermatopathology

Discussions

Discoid lupus erythematosus and dermatomyositis have more findings histopathologic in common than they have differences. Both diseases are characterized by compact orthokeratosis, an epidermis thinned focally, a pattern of rete ridges and dermal pap…

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

…osis histopathologic Classic discoid lupus erythematosus and dermatomyositis may display changes indistinguishable in every way from those of Degos’ disease. In most instances, Degos’ disease actually is an expression of lupus erythemato…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

…H has been reported, in an 8-year-old child who suffered from dermatomyositis. We report another child with juvenile CNH who was not afflicted with dermatomyositis or other systemic disorders. The clinical and histologic evaluations demonstrated CNH…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…he lesion. Last, it must be acknowledged that some lesions of dermatomyositis are indistinguishable from some of those of classic discoid lupus erythematosus. In both diseases, mucin is increased in the reticular dermis and a thickened basement membr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

…220;Skin biopsies from patients with scleroderma and juvenile dermatomyositis share many histologic features. Characteristics common to both diseases are particularly evident in the dermal microvasculature and include endothelial swelling and concent…

Histologic Diagnosis of Inflammatory Skin Diseases

Bibliography

Bibliography Bibliography for dermatomyositis el-Azhary RA, Pakzad SY. Amyopathic dermatomyositis: retrospective review of 37 cases. J Am Acad Dermatol 2002;46(4):560-65. Golitz LE. Collagen diseases. J Cutan Pathol 1985;12:358-65. Hepp. Über Pseudo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…ematosus. Systemic lupus erythematosus may be contrasted with dermatomyositis, systemic sclerosis, and Sj?gren’s syndrome, but not with skin diseases like poikilodermatomyositis, morphea, or discoid lupus erythematosus. Just as dermatomyositis

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…cular infiltrate of lymphocytes = Discoid lupus erythematosus/Dermatomyositis + Smudged appearance of the dermoepidermal interface, thin epidermis focally, and a moderately dense perivascular infiltrate of lymphocytes = Discoid lupus erythematosus…