Search Results for: dermis

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…ils scattered among collagen bundles throughout the reticular dermis Edema of the papillary dermis Epidermal necrosis and erosion or ulceration Fully developed Perivascular lymphoplasmacytic infiltrates around venules in at least the upper part of th…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…he subcutaneous fat also are present throughout the reticular dermis of necrobiosis lipoidica. Adipocytes in lobules are approximated so close to one another normally that they seem to be arranged in a syncytium. Those fat cells, referred to also as…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…her ectoderm or mesoderm. The epithelial structures, i.e., epidermis (surface and infundibular), apocrine units, sebaceous units, hair follicles, eccrine units, and nail units, come from ectoderm. Melanocytes, nerves, and specialized sensory receptor…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…asiform lichenoid + 11.14.1B: Lymphocytes, sparse in both the dermis and epidermis, larger in the epidermis than in dermis, solitary in the basal layer in foci, and in association with scant spongiosis in the spinous zone = Mycosis fungoides, patch  …

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…and by fissures that form within the abnormally cornified epidermis. In short, without firm grounding in structure and function of skin, a histopathologist lacks a basis for making diagnoses logically of inflammatory skin diseases, and a clinician l…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…ls scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/or eosinophils sprinkled along the dermoepidermal junction in conjunction with vacuolar alteration Slight spongiosis and ballooning Indiv…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…calvans]) refers to lichen planus centered in infundibular epidermis and in follicles, it tending largely to spare surface epidermis and to end in permanent alopecia; the end-stage of alopecic lesions on the scalp is known as pseudopelade of Brocq, a…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…cature of lupus tumidus, the amount of mucin in the reticular dermis being so great that plaques with a papillated surface come into being, they being associated with but paltry perivascular infiltrates of lymphocytes. Reticular erythematosus mucinos…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

…brin thrombi in the lumen of venules in the upper part of the dermis mostly; sometimes, the lower half of the dermis is affected and, episodically, the subcutaneous fat Numerous erythrocytes extravasated in the upper part of the dermis Fully develope…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…; An exceptional finding in the absence of necrosis of the epidermis is numerous neutrophils in an intraepidermal vesicle induced by the “bite” of an insect. Necrosis, in general, is chemotactic for neutrophils. 10.5.4A: Vesicular dermati…