Search Results for: dermis

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…the dermis, whereas those of radiation dermatitis, as a rule, involve at least more than half the thickness of the reticular dermis, often the entire dermis, and sometimes part of the subcutaneous fat, too. If biopsies of the two conditions, lichen…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat: Panniculitis

…Diagnosis histopathologic of both of those panniculitides/dermatitides often is accomplished best by noting findings in the dermis, as well as in the hypodermis. Not surprisingly, the septal panniculitis of erythema nodosum begins with neutrophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Embryologic Development

…o skin that is smooth and which sports vellus hairs, but not terminal ones. Early in embryogenesis, the interface between epidermis and dermis is flat. During the first trimester, a basement membrane, synthesized mostly by epidermal basal cells,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…only, they become papules and plaques. 11.14.5A: Perivascular dermatosis, spongiotic + 11.14.5B: Abnormal lymphocytes in the dermis and epidermis, in the latter in association with scant spongiosis = Mycosis fungoides, plaque Even at low…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…eccrine units. A fully formed dermis is divisible into two distinct compartments: (1) a thin zone immediately beneath the epidermis (papillary dermis) and around adnexa (periadnexal dermis) and (2) a thick zone (reticular dermis) that extends from…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…A: Perivascular dermatitis, interface, vacuolar type + 10.25.19B: Lymphocytes, neutrophils, and eosinophils in the papillary dermis and necrosis of an epidermis covered by a normal cornified layer + 10.25.19C + 10.25.19D = Fixed drug eruption The…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…ion developed fully is a thickened basement membrane beneath a thinned epidermis, at least in foci; the interface between epidermis and dermis has a smudged appearance. Lichenoid purpura of Gougerot and Blum is differentiated by the presence of…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…mbrane may be seated beneath a thinned surface epidermis and along a thinned infundibular epidermis, the junction between epidermis and dermis often having a smudged appearance. When an infiltrate of lymphocytes is dense and deep, the diagnosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Livedo vasculitis

…y in the upper part of the dermis Sclerosis in the upper part of the dermis Numerous telangiectases in the upper part of the dermis Epidermis thinned markedly and largely devoid of rete ridges Correlation clinicopathologic Active lesions of livedo…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…y the insect. 10.5.36A: Vesicular dermatitis, intraepidermal and subepidermal + 10.5.36B: Lymphocytes and eosinophils in the dermis and spongiosis and ballooning in the epidermis + 10.5.36C + 10.5.36D = Response to an assault by an arthropod A…