Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…too, for acantholytic dyskeratotic acanthoma, but acantholytic dyskeratosis does occur in an inflammatory disease, namely, the “Darier manifestation” of Grover’s disease (Fig. 5.273 A&B). A focus of “acantholytic dyskerato…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…atosis characterized histopathologically by focal acantholytic dyskeratosis, i.e., acantholytic dyskeratotic acanthoma, and from an incidental finding histopathologic of focal acantholytic dyskeratosis. Such a focus may be indistinguishable, too, fro…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…eratoma, the solitary keratosis marked by foci of acantholytic dyskeratosis (acantholytic dyskeratotic acanthoma), the epidermal nevus typified by foci of acantholytic dyskeratosis, and in Darier’s disease all cornify abnormally. ACANTHOSIS [Gk…

Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

…erized by changes throughout its circumference of acantholytic dyskeratosis, initially was called “isolated dyskeratosis follicularis,” implying a relationship with Darier’s disease, which originally was termed “keratosis foll…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.7.1A: Perivascular dermatosis + 11.7.1B: Foci of acantholytic dyskeratosis = Darier’s disease ┬áChanges in the epidermis identical to these may be seen in one expression, namely, the Darier, of Grover’s disease, as we…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

By utilizing an algorithmic method based mostly on analysis of patterns formed by inflammatory cells, of alterations in epidermal and adnexal epithelium, and of the character of the inflammatory cells themselves, order can be brought to a subject ab…

Differential Diagnosis in Dermatopathology

Discussions

Darier’s disease and Grover’s disease have several findings histopathologic in common, among them foci of acantholytic dyskeratotic cells in the epidermis and a superficial perivascular infiltrate of inflammatory cells, usually lymphocyt…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…