Histologic Diagnosis of Inflammatory Skin Diseases

Bullous pemphigoid

…Perivascular and interstitial infiltrate of lymphocytes and eosinophils Eosinophils scattered throughout the upper part of the reticular dermis, in the edematous papillary dermis, and along the dermoepidermal junction Eosinophils often in the epide…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…iltrate of lymphocytes around venules mostly; neutrophils and eosinophils scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/or eosinophils sprinkled along the dermoepidermal junction in conj…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…i look from afar like tiny gray dots) (Fig. 6.4 A&B); and eosinophils are red (because of the hue of their numerous coarse cytoplasmic granules) (Fig. 6.5 A&B). Even though a decision about the identity of inflammatory cells can be corroborat…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…arly Superficial perivascular and interstitial infiltrate of eosinophils mostly Slight edema of the papillary dermis Spongiosis accompanied by eosinophils in surface epidermis Cornified layer normal Fully developed Numerous eosinophils in the uppe…

Histologic Diagnosis of Inflammatory Skin Diseases

Drug eruptions

…ytes (some of them in clusters), and the presence at times of eosinophils; each of those signify likelihood, in the setting of a lichenoid dermatitis, of a drug being causative. All the changes just mentioned may not be present together in a particul…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…ory cells are characterizations accurately of neutrophils and eosinophils on one hand and of lymphocytes and histiocytes on the other. Reason: Because neutrophils and eosinophils may be present in large numbers in a long-standing (chronic) inflammato…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…vascular dermatitis, mixed-cell + 10.111.1B: Lymphocytes, eosinophils, and a few neutrophils around venules = Urtica, early ¬†This is an early stage in the evolution of urticaria because inflammatory cells are huddled around venules; interstitial…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…r superficial and deep perivascular infiltrate of lymphocytes Eosinophils sometimes present in the dermal infiltrate Lymphocytes in lichenoid array, if only focally; some dermal papillae may be stuffed with lymphocytes Wiry bundles of collagen arrang…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…In short, the granulomas they described, despite the numerous eosinophils associated with them, cannot be said to be allergic on grounds histopathologic alone. Thus, on the basis of a single finding histopathologic, i.e., an “allergic granuloma…