Histologic Diagnosis of Inflammatory Skin Diseases

Bullous pemphigoid

…) Perivascular and interstitial infiltrate of lymphocytes and eosinophils Eosinophils scattered throughout the upper part of the reticular dermis, in the edematous papillary dermis, and along the dermoepidermal junction Eosinophils often in the epid…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…filtrate of lymphocytes around venules mostly; neutrophils and eosinophils scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/or eosinophils sprinkled along the dermoepidermal junction in con…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…Schamberg”s disease (see Fig. 5.25), of lymphocytes and eosinophils, as in a type of drug eruption (see Fig. 5.28), and of lymphocytes, neutrophils, and eosinophils, as in urtica (see Fig. 5.123). Figure 6.1 A&B. Identification of lymph…

Histologic Diagnosis of Inflammatory Skin Diseases

Incontinentia pigmenti

…Early Superficial perivascular and interstitial infiltrate of eosinophils mostly Slight edema of the papillary dermis Spongiosis accompanied by eosinophils in surface epidermis Cornified layer normal Fully developed Numerous eosinophils in the upp…

Histologic Diagnosis of Inflammatory Skin Diseases

Drug eruptions

…lichenoid drug eruptions harbor at least one of them. If many eosinophils are noted in a lichenoid dermatitis, almost certainly it is a lichenoid drug eruption. A sprinkling of eosinophils, however, may be found in a host of inflammatory processes t…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…tory cells are characterizations accurately of neutrophils and eosinophils on one hand and of lymphocytes and histiocytes on the other. Reason: Because neutrophils and eosinophils may be present in large numbers in a long-standing (chronic) inflammat…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cells are huddled around venules; interstitial involvement by eosinophils and neutrophils is slight. 10.111.2A: Perivascular and interstitial dermatitis, mixed-cell + 10.111.2B: Lymphocytes, eosinophils, and neutrophils around venules, and…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…a mucinosis”) Comedo-like plugs of infundibula sometimes Eosinophils in the interstitium of the reticular dermis, at times many of them Eosinophils sometimes present in infundibular epidermis Involvement of sebaceous glands Lymphocytes solita…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…saded granulomas that house polymorphs (i.e., neutrophils) and eosinophils, those two kinds of granulocytes being present in variable proportions. Some contend that neutrophils predominate, whereas others insist that eosinophils are preponderant. Wha…