Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

…mal. Although most pustules in skin are housed in infundibular epidermis (Fig. 5.308 A&B), many are lodged in surface epidermis (Fig. 5.309 A&B). Irrespective of whether a pustule comes to be situated in infundibular epidermis or in surface e…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ion in company with vacuolar alteration and a markedly thinned epidermis = Lupus erythematosus, discoid ¬†Only a very few inflammatory diseases of the skin are associated with a very thin epidermis, as shown here, those being discoid lupus erythematos…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…s decalvans]) refers to lichen planus centered in infundibular epidermis and in follicles, it tending largely to spare surface epidermis and to end in permanent alopecia; the end-stage of alopecic lesions on the scalp is known as pseudopelade of Broc…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mammary and Extramammary Paget’s Disease?

…ells of an apocrine carcinoma proliferate first within surface epidermis and, just like melanoma, descend infundibular epidermis and eccrine ducts. In contrast, in mammary Paget’s disease, cells of an apocrine carcinoma take origin from lactife…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…llaries, thin rete ridges of about equal length, pallor of the epidermis, and neutrophils in mounds of parakeratosis = Psoriasis, near fully developed ¬†That this lesion still is evolving as can be told by pallor in the upper part of the epidermis and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…vertical streaks, proliferation of keratocytes of infundibular epidermis, as well as of surface epidermis, hypergranulosis, and compact orthokeratosis = Lichen simplex chronicus (“epidermal and dermal” type) When the skin has been rubbed…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…soriasiform acanthosis, pallor in the upper part of the viable epidermis, and an infiltrate of mononuclear cells in the dermis, but also because of the presence at times, in both conditions, of neutrophils in the epidermis, sometimes in spongiform pu…