Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

…al. Although most pustules in skin are housed in infundibular epidermis (Fig. 5.308 A&B), many are lodged in surface epidermis (Fig. 5.309 A&B). Irrespective of whether a pustule comes to be situated in infundibular epidermis or in surface ep…

Histologic Diagnosis of Inflammatory Skin Diseases

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…ed appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid  The presence of parakeratosis does not militate against a diagnosis of discoid lupus erythematosus. In…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…decalvans]) refers to lichen planus centered in infundibular epidermis and in follicles, it tending largely to spare surface epidermis and to end in permanent alopecia; the end-stage of alopecic lesions on the scalp is known as pseudopelade of Brocq…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mammary and Extramammary Paget’s Disease?

…he invasion of carcinoma cells (Paget’s cells) into the epidermis and into the glandular portion of the sweat gland.” Braun-Falco O, Plewig G, Wolff HH, et al. Precanceroses. In: Dermatology. Berlin, Germany: Springer-Verlag, 1991:1005….

Histologic Diagnosis of Inflammatory Skin Diseases

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…the disease. In brief, lymphocytes precede neutrophils in the epidermis of an incipient lesion of psoriasis, and they induce spongiosis there. The spongiotic character of psoriasis is appreciated best in lesions that develop on palms and soles….

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ng period of time. The alterations are confined mostly to the epidermis and thickened papillary dermis. 10.23.2A: Perivascular dermatitis, psoriasiform, markedly hyperkeratotic + 10.23.2B: Orthokeratosis, hypergranulosis, acanthosis, prolif…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…cks plasma cells, and usually is devoid of involvement of the epidermis. Clues to specific diagnosis histopathologic Striking pallor of cells in the upper part of the spinous zone and the granular layer is a clue to deficiency diseases such as pell…