Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…cin.” The authors observed an increase in the number of fibrocytes and of small blood vessels in most of the lesions. They thought the condition represented a special type of “cutaneous fibroma” that might be a histopathologic hallm…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…: Markedly thickened bundles of collagen accompanied by plump fibrocytes, both of them in haphazard array = Keloid In the evolution of a keloid, the thick collagen bundles shown follow on formation of fibrillary collagen bundles. In an early stage of…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…ully developed Thin bundles of collagen accompanied by plump fibrocytes are oriented parallel to the skin surface Dilated venules oriented mostly perpendicular to the skin surface Mucin sometimes abundant Elastic fibers absent Late All the finding…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ibrosing dermatitis + 10.23.10B: Increased number of thin fibrocytes in company with fibrillary bundles of collagen in the upper part of the dermis and parallel to the skin surface beneath a scale-crust = Scar secondary to excoriation All the cha…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…ipophages, coarse bundles of collagen in haphazard array, and fibrocytes dispersed between thickened bundles of collagen at the periphery of the nodular infiltrate = Dermatofibroma + Angiocentricity of collections of foamy histiocytes on an eyelid…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…followed by lymphocytes and, sometimes, histiocytes and later fibrocytes. A caricature of that phenomenon is what follows on rupture of an infundibular cyst, namely, suppuration, granulomatous infiltration, and fibrosis; of course, a plug of corneocy…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…and panniculitis, septa + 10.69.1B: Patchy infiltrates of fibrocytes in association with fibrillary bundles of collagen throughout much of the reticular dermis and in some septa of the subcutaneous fat + 10.69.1C + 10.69.1D = Nephrog…