Histologic Diagnosis of Inflammatory Skin Diseases

Images

…: Numerous thick bundles of collagen in haphazard array, plump fibrocytes, and abundant mucin in interstices between bundles of collagen = Keloid In an evolving keloid, such as this one, plump fibrocytes are aligned parallel to thickened collagen bun…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

…; Three of the lesions were hypocellular with scant, elongated fibrocytes positioned as solitary units among bundles of collagen, whereas the other lesion showed a proliferation of plump fibrocytes among bundles of collagen. Some giant cells resemble…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…s), in company with innumerable extravasated erythrocytes, and fibrocytes in conjunction with coarse bundles of collagen, both components being arranged randomly. At the periphery of the poorly circumscribed lesion, histiocytes and fibrocytes are int…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…+ Sclerosis throughout much or all of the dermis with abnormal fibrocytes in the upper part of it = Radiation sclerosis + Fibrin beneath a cleft and chondrocytoid fibrocytes in granulation tissue at the sides of it = Chondrodermatitis nodularis hel…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

What follow now are our definitions of the terms inflammation and inflammatory disease as we employ them in this volume. Inflammation. Changes in tissue that occur typically as a reaction to injury of any kind (e.g., mechanical, actinic, chemical,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.23.1A: Perivascular dermatitis, psoriasiform + 10.23.1B: Orthokeratosis, hypergranulosis, acanthosis, proliferation of infundibular and eccrine ductal keratocytes, and coarse bundles of collagen in vertical streaks = Lichen simp…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.69.1A: Fibrosing dermatitis and panniculitis, septa + 10.69.1B: Patchy infiltrates of fibrocytes in association with fibrillary bundles of collagen throughout much of the reticular dermis and in some septa of the subcutaneous fa…