Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…exudate, severe “fibrinoid” collagen change, and granulomatous proliferation of epithelioid and giant cells. This is considered a histopathologic entity termed “allergic granuloma.” Churg J, Strauss L. Allergic granulomatosi…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyogenic granuloma

Pyogenic granuloma Synonyms Capillary hemangioma Presentation stereotypical Age and sex Children and young adults of both sexes Distribution of lesions Fingers and toes, lips, buccal mucosa, and trunk Individual lesions Sessile papules at first ulce…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

Granuloma faciale Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the face Shape of lesions Round or oval usually Individual lesions Papules, plaques, nodules, or tumors marked on their surface often…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

Miescher’s granuloma of the face Presentation stereotypical Age and sex Women Distribution of lesions Face and scalp Configuration of lesions Annular Individual lesions Plaques Course Resolving after many months Differential diagnosis clinical…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Dermatology Practical & Conceptual

Actinic granuloma

Actinic granuloma is a rare, idiopathic disorder of middle-aged adults that always appears in sun-exposed skin [1,2]. It is a form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins that…