Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…c exudate, severe “fibrinoid” collagen change, and granulomatous proliferation of epithelioid and giant cells. This is considered a histopathologic entity termed “allergic granuloma.” Churg J, Strauss L. Allergic granulomatos…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyogenic granuloma

…s and venules in the lesion, but are not specific for pyogenic granuloma. Cause and mechanism Pyogenic granuloma is thought to be a response to injury external. Comment At an early stage, pyogenic granuloma resembles “proud flesh” clinica…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

Granuloma faciale Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the face Shape of lesions Round or oval usually Individual lesions Papules, plaques, nodules, or tumors marked on their surface often…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…d mechanism Both are unknown. Comment Whether Miescher’s granuloma of the face, a diagnosis made rarely, is a specific disease or a mere variant of granuloma annulare has yet to be determined. The findings are limited to the reticular dermis, w…

Differential Diagnosis in Dermatopathology

Subcutaneous granuloma annulare vs. Rheumatoid nodule

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Dermatology Practical & Conceptual

Actinic granuloma

Actinic granuloma is a rare, idiopathic disorder of middle-aged adults that always appears in sun-exposed skin [1,2]. It is a form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins that…