Search Results for: histiocytes

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…fibrosis in the dermis and the upper part of the subcutaneous fat. Many small blood vessels are present in the infiltrate of histiocytes and fibrocytes, and the epidermis is acanthotic—findings common in dermatofibroma. 10.20.5A: Fibrosing…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ta has encroached markedly on lobules, nearly obliterating some of them. 10.52.7A: Perivascular and interstitial dermatitis; histiocytes mostly + 10.52.7B: Histiocytes in interstitial and palisaded array, many neutrophils scattered among the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…granulomatous inflammation in response to silicone. 10.38.16A: Nodular panniculitis, granulomatous + 10.38.16B: Epithelioid histiocytes, some of them multinucleate, in collections, many histiocytes with vacuolated cytoplasm, and spaces artifactual…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…re present in collections in skin of an eyelid, the diagnosis is xanthelasma. If, in the context of a proliferation of foamy histiocytes, abundant lipid is apparent extracellularly, the diagnosis is eruptive xanthoma. If foamy histiocytes are…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…n of histiocytes and plasma cells. Mucha-Habermann disease is composed almost entirely of lymphocytes, rather than mostly of histiocytes and plasma cells. Psoriasis lacks plasma cells and histiocytes, and usually involves the superficial plexus…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…organs infected by Mycobacterium tuberculosis. The equivalent histopathologic of tubercles in tuberculosis is collections of histiocytes with plump oval nuclei and abundant pale-pink cytoplasm. Because those histiocytes appear to be contiguous with…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…one another because their nuclei are so dark and their cytoplasm so scant. Figure 6.2 A&B. Identification of epithelioid histiocytes at scanning and high magnifications. Histiocytes in this lesion of sarcoidosis can be identified for what they…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat: Panniculitis

…erythema nodosum begins with neutrophils being predominant in edematous septa (Fig. 5.404 A&B), proceeds to epithelioid histiocytes becoming dominant, and ends with fibrosis in the absence of an infiltrate of inflammatory cells (see Fig. 5.386…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…B: Epithelioid histiocytes aligned in a palisade around foci of degenerated collagen and necrosis of inflammatory cells, the histiocytes in turn being encircled by lymphocytes = Sarcoidosis Tuberculoid granulomas made up of collections of…

Histologic Diagnosis of Inflammatory Skin Diseases

Sarcoidosis

…e subcutaneous fat; granulomas usually discrete, but may be confluent Tiny focus of necrosis in the center of collections of histiocytes sometimes Multinucleate histiocytes sometimes present in the granulomas Inclusions, i.e., asteroid bodies…