Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Fibromatoses?

“Benign tumors and tumor-like proliferations Fibromatoses Fibroma molle Nonmetastasizing fibrosarcomas Desmoid tumor Keloid Cicatricial fibromatosis Palmar fibromatosis (fibroma or pseudotumor of Dupuytren’s contracture) Plantar fibroma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…hrocytes present mostly in slits between spindle cells 7. No hyaline globules within endothelial cells 7. Hyaline globules within some endothelial cells 8. Extravasation of erythrocytes and deposits of hemosiderin in the stroma in loci 8. Extrava…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

Granuloma faciale Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the face Shape of lesions Round or oval usually Individual lesions Papules, plaques, nodules, or tumors marked on their surface often…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atrophie Blanche?

“In any event, it is a special form of cutaneous atrophy in its presentation, a real idiopathic malady, i.e., if you do not wish to attribute it to syphilis, [and] we designate it ‘atrophie blanche.’ … Histologic examination…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

“… this distinctive type of necrosis (apoptosis)…has previously been called shrinkage necrosis on morphological grounds.” Kerr JFR. Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implicatio…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

“In PLEVA, the more severe form, one observes vascular changes consisting of a pronounced mononuclear infiltrate around capillaries, with the capillaries showing endothelial swelling and permeation of their walls by the infiltrate. This usua…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

“The occurrence of a clinical syndrome of severe asthma, fever, and hypereosinophilia, together with symptoms of vascular embarrassment in various organ systems, has been established. . . . The basic anatomical changes . . . consisted of wide…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

“An irreversible alopecia of the scalp occurs in negro women who straighten their hair with hot combs. The disease is common and distinctive, clinically and histopathologically. . . . Hot petrolatum used with the comb causes a chronic inflamm…