Search Results for: hyperkeratosis

A Clinical Atlas of 101 Common Skin Diseases

Palmar and Plantar Keratoderma

A keratotic condition of the palms and soles, inherited usually, but sometimes acquired, in which involvement may be diffuse, circumscribed (including striate), or punctate.

Resolving Quandaries in Dermatology, Pathology & Dermatopathology


…granular layer is prominent in this condition. Epidermolytic hyperkeratosis consists of a clinical spectrum of disorders; generalized forms may be bullous, and localized forms may resemble linear nevi. Intracellular and intercellular edema gives the…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…e pattern. Figure 3.19 A. Hypergranulosis. B. Hypogranulosis. HYPERKERATOSIS [Gk. hyper (above) + keratos (horn) + –osis (condition)]: A thickened cornified layer of an epithelium, usually an epidermis (surface and infundibular), but sometimes…

Differential Diagnosis in Dermatopathology


Epidermolytic hyperkeratosis and a plane wart share several findings histopathologic, among them being a papillated and thickened epidermis, hypergranulosis, and cells with pale cytoplasm within the epidermis. The terms “epidermolytic hyperker…

Histologic Diagnosis of Inflammatory Skin Diseases


…ar dermatitis, psoriasiform, eroded and ulcerated + 10.23.8B: Hyperkeratosis, proliferation of keratocytes of surface and infundibular epidermis, and coarse bundles of collagen in vertical streaks in a thickened papillary dermis = Lichen simplex chro…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Subacute Cutaneous Lupus Erythematosus?

…a mononuclear cell-rich pattern is seen. Follicular dilation, hyperkeratosis, and plugging are much more prominent in the chronic scarring lesions of DLE. In general, the histopathologic features of SCLE and DLE are qualitatively identical, differing…

Dermatology Practical & Conceptual

Keratotic papules of palms and soles

…biopsy obtained from a lesion revealed marked orthokeratotic hyperkeratosis with hypergranulosis (Figure 3). What is your diagnosis? Figure 1. Multiple keratotic crateriform papules over the palms. [Copyright: ©2015 Maione et al.] Figure 2. Numerous…