Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…inically) Superficial perivascular and variably interstitial infiltrate of lymphocytes Subtle patchy lichenoid infiltration of lymphocytes not uncommonly Lymphocytes disposed as solitary units in some loci of the epidermal basal layer Lymphocytes sp…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…hologic Early Wedge shape of a perivascular and interstitial infiltrate of inflammatory cells in response to a “bite” of an insect Lymphocytes and eosinophils around venules, and eosinophils scattered in the interstitium of the reticular…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…always in conjunction with superficial and deep perivascular infiltrates in which histiocytes and plasma cells, in time, come to predominate over lymphocytes. The lichenoid infiltrate of secondary syphilis, especially in the context of a superficia…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…lar dermatitis, interface, vacuolar + 10.63.6B: Lichenoid infiltrate of lymphocytes and melanophages, thickened basement membrane, and thin epidermis = Lupus erythematosus, discoid  A thickened epidermal basement membrane, like the one illustrate…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…blush, may appear to be inflammatory cells) that make up the infiltrate. Remarkable as it may seem, specific types of inflammatory cells often can be recognized for what they are at scanning magnification as follows: lymphocytes are black dots that…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…uently, but not always, around vessels and/or appendages. The infiltrates consist of lymphocytes, mostly small ones, and usually a few histiocytes and plasma cells.” Jessner M, Kanof NB, Orfuss AJ. Lymphocytic infiltration of the skin. Arch De…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…ial and usually deep perivascular and interstitial mixed-cell infiltrate of lymphocytes around venules mostly; neutrophils and eosinophils scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/o…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…assessments being predicated entirely on the predilection of infiltrates of inflammatory cells in regard to distribution of them as judged at scanning power. In general, “mostly lobular” panniculitides greatly outnumber “mostly sep…