Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…ophy clinically) Sparse superficial perivascular interstitial infiltrate of lymphocytes Subtle patchy lichenoid infiltrate of lymphocytes in a papillary dermis thickened also by wiry bundles of collagen in haphazard array Loss of the usual undulate…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…pathologic Papules are formed by perivascular and interstitial infiltrates of inflammatory cells coupled with edema housed mostly in the papillary dermis. Some papules are made up of nodular infiltrates, the exemplar being those of nodular scabies. P…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…y always in conjunction with superficial and deep perivascular infiltrates in which histiocytes and plasma cells, in time, come to predominate over lymphocytes. The lichenoid infiltrate of secondary syphilis, especially in the context of a superfici…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.63.1A: Perivascular dermatitis, interface, vacuolar + 10.63.1B: Smudged appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid ┬áThe presence…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…easily at scanning magnification because they are bright red. Infiltrates of inflammatory cells may be categorized as either monomorphous or mixed. “Monomorphous” refers to an infiltrate that consists of a single type of inflammatory cel…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…uent about the enigmatic facial plaques formed by perivascular infiltrates of lymphocytes. Nonetheless, because such infiltrates are observed so commonly in sections of biopsy specimens removed from reddish plaques on a face, and because all too ofte…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…isease also involve the dermis; there is no wedge shape to the infiltrate of fixed drug eruption and the infiltrate is mixed, not a pure population of lymphocytes. Later lesions of Mucha-Habermann disease, unlike those of fixed drug eruption and of e…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…ic fibers in addition to signs of lymphoma seen here as patchy infiltrates of lymphocytes in the subcutaneous fat and in the reticular dermis, a lichenoid infiltrate of lymphocytes in company with wiry bundles of collagen in haphazard array, and lymp…