Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

…osis, are euphemisms for various types of superficial squamous cell carcinoma. Very episodically, neoplastic cells of those types of squamous cell carcinoma proliferate wildly, and the primary neoplasm then consists of aggregations that extend throug…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

…GI complaints, and headaches can result from circulating mast cell products released when the mastocytoma is rubbed or irritated. These symptoms may require treatment. Treatment First steps Children with localized mast cell tumors are best treated b…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

Malignant neoplasms of B-lymphocytes especially that present themselves usually as papules, nodules, and tumors, sometimes solitary but at other times numerous, and often in clusters on any anatomic site. When “primary,” B-cell lymphomas o…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

…y Paget’s is almost always associated with an underlying carcinoma. The data on extramammary Paget’s are less clear, but between 25% and 50% have an associated carcinoma. A careful lymph node evaluation is essential. Immunoperoxidase mark…

A Clinical Atlas of 101 Common Skin Diseases

Nevus Sebaceus

A hamartoma of epidermis, epithelial structures of adnexa, and presumably dermal elements, typified, when fully formed, by a papillated or verrucous yellowish plaque situated usually on the scalp. The condition may present itself as a solitary lesio…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

Overview Therapy of cutaneous T-cell lymphoma often requires specialized knowledge, and for this reason it is often appropriate to refer such patients to a medical center with specialized knowledge in the management of CTCL. Since early aggressive t…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Chondrodermatitis Nodularis Helicis: Key Points

…sions are often mistaken for non-melanoma skin cancers (either basal cell or squamous cell carcinomas). Unlike those cutaneous malignancies, CNH is a benign entity. Pain is a critical feature, as CNH is invariably symptomatic, though patients may not…