Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…An epidermis that exhibits nuclei characterized mostly by karyolysis and cytoplasm typified by eosinophilia across a front of at least several millimeters. Click image to enlarge. + Lymphocytes and vacuolar alteration along the dermoepidermal int…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…is in the upper part of the epidermis. Necrosis, evidenced by karyolysis especially, in the upper half of the viable epidermis is a result of external injury, in this instance in the form of scratching furiously, so uncontrollably that an ulcer, seen…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…mis indicates that the lesion was induced by injury external. Karyolysis and pink cytoplasm of some ballooned keratocytes are indications of necrosis. Neutrophils are sprinkled in the upper half of the epidermis, likely in response to necrosis of ker…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…. Extensive necrosis en masse of adipocytes; karyorrhexis and karyolysis striking 7. Necrosis of adipocytes manifested mostly by karyorrhexis; karyolysis present, but subtle 8. Membanous fat necrosis 8. No membranous fat necrosis 9. Marked sclero…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Chondrodermatitis Nodularis Helicis?

…to them may be perichondral sclerosis and signs of necrosis (karyolysis) of cartilage. In summary, chondrodermatitis nodularis helicis is neither a primary disease of cartilage nor even a primary disease of the skin itself, but a response to externa…

Differential Diagnosis in Dermatopathology

Discussions

…d by nuclear changes alone, i.e., pyknosis, karyorrhexis, and karyolysis. In a normal adipocyte, however, the tiny nucleus is pushed by huge quantities of intracytoplasmic lipid to the side of the cell and, therefore, a histopathologist must look els…