Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…in (and subcutaneous fat) usually derives from fragmentation (karyorrhexis) of nuclei of neutrophils (Fig. 5.208 A&B), at times disintegration of nuclei of lymphocytes (Fig. 5.209 A&B) is observed in sections of tissue of diseases as unalike…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…c pathology, distinctive changes in nuclei, namely, pyknosis, karyorrhexis, and karyolysis, are indicators essential of necrosis. In fat lobules, however, most nuclei are missed as a microtome slices through rotund adipocytes, and, that being the cas…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es in this disease induced by a virus show signs of extensive karyorrhexis. 11.2.2A: Nodular and diffuse dermatosis + 11.2.2B: Abnormal lymphocytes in the dermis and in discrete aggregations in the epidermis = Adult T-cell leukemia/lymphoma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…large vessels 7. Extensive necrosis en masse of adipocytes; karyorrhexis and karyolysis striking 7. Necrosis of adipocytes manifested mostly by karyorrhexis; karyolysis present, but subtle 8. Membanous fat necrosis 8. No membranous fat necrosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

…s composed mostly of neutrophils, some of which show signs of karyorrhexis, i.e., nuclear “dust,” and erythrocytes extravasated in variable numbers. Those paltry findings, though, are nearly as specific for diagnosis of leukocytoclastic v…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ratocytes show signs of necrosis, in particular, pyknosis and karyorrhexis. 10.47.3A: Vesicular dermatitis, intraepidermal, acantholytic and ballooned + 10.47.3B: Keratocytes with steel-gray nuclei, “margination” of chromatin, a…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…sation of erythrocytes, and an infiltrate of neutrophils with karyorrhexis of nuclei (i.e. leukocytoclasia) are major features of cutaneous small vessel vasculitis.” Barham KL, Jorizzo JL, Grattan B, et al. Vasculitis and neutrophilic vascular…

Differential Diagnosis in Dermatopathology

Discussions

…necrosis is judged by nuclear changes alone, i.e., pyknosis, karyorrhexis, and karyolysis. In a normal adipocyte, however, the tiny nucleus is pushed by huge quantities of intracytoplasmic lipid to the side of the cell and, therefore, a histopatholo…