Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.2.1A: Perivascular dermatosis, lichenoid + 11.2.1B: Abnormal lymphocytes in the dermis and in discrete collections in the epidermis = Adult T-cell leukemia/lymphoma ┬áThe intraepidermal clusters of abnormal lymphocytes resemble t…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…large vessels 7. Extensive necrosis en masse of adipocytes; karyorrhexis and karyolysis striking 7. Necrosis of adipocytes manifested mostly by karyorrhexis; karyolysis present, but subtle 8. Membanous fat necrosis 8. No membranous fat necrosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

Leukocytoclastic vasculitis Synonyms Leukocytoclastic angiitis Allergic vasculitis Hypersensitivity angiitis Hypersensitivity vasculitis Anaphylactoid purpura Immune complex vasculitis Purpura rheumatica Presentation stereotypical Age and sex Any ag…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.47.1A: Perivascular dermatitis, interface, patchy lichenoid + 10.47.1B: Keratocytes with steel-gray nuclei, “margination” of chromatin, ballooned cytoplasm, and multinucleate and necrotic keratocytes = Infection by h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

“The term necrotizing angiitis has proved to be a convenient generic term for the entire group of vascular lesions, both arterial and venous, in which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving…

Differential Diagnosis in Dermatopathology

Discussions

Changes histopathologic in both lupus erythematosus profundus and panniculitis-like T-cell lymphoma involve the subcutaneous fat especially where they have in common an infiltrate, in lobules and septa, comprised mostly of lymphocytes, fat necrosis…