Search Results for: langerhans\\' cells

Therapeutic Strategies in Dermatology

Seborrheic Dermatitis: Principles of Seborrheic Dermatitis Management

…is-like picture can be the presenting feature of all forms of Langerhans’ cell histiocytoses and other rare inherited or congenital disorders (e.g., Hailey-Hailey disease, primary immunodeficiencies). Seborrheic dermatitis tends to recur and re…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…rous intermingling eosinophils were present. The diagnosis of Langerhans cell histiocytosis was then rendered and confirmed by positive immunostaining of neoplastic cells for anti-CD1a and anti-S100 protein antibodies. The work-up revealed diabetes i…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

“Tumor cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO: C…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

…“A nevus (mole) is a benign neoplasm of pigment-forming cells, the nevus cell.” Lookingbill DP, Marks JG Jr. Principles of clinical diagnosis. In: Moschella SL, Hurley HJ, eds. Dermatology. 3rd ed. Philadelphia, PA: WB Saunders Co., 1992:…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

….e., cancer, exhibits the properties of: 1. invasion when its cells infiltrate the surrounding normal tissue; and 2. metastasis, the capacity of cancer cells to spread and grow at sites distant from the origin of the neoplasm.” Harnden DG, McGe…

Histologic Diagnosis of Inflammatory Skin Diseases

Merkel Cells

…sence of any seeming association with neural elements. Merkel cells appear in fetal skin by the 16th week of gestation, and, unlike melanocytes, they do not come from the neural crest, and, unlike Langerhanscells, they do not come from the bo…

Differential Diagnosis in Dermatopathology

Dermatofibroma with "monster" cells vs. Malignant fibrous histiocytoma

A proliferation of abnormal Langerhanscells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Therapeutic Strategies in Dermatology

Candidiasis: Initial Evaluation

Initial Evaluation Candidiasis Intertriginous Oral Paronychia Differential diagnosis Inverse pityriasis rosea Deficiency dermatitis (such as zinc deficiency, aka acrodermatitis enteropathica) Allergic or irritant contact dermatitis Inverse psoriasis…