Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…, 2nd ed. Sydney: Churchill Livingstone: 2002:1079. The term Langerhans’ cell granulomatosis is in vogue for diseases characterized by infiltrates in which Langerhanscells predominate, namely, Letterer-Siwe disease, Hand-Sch?ller-Chri…

Therapeutic Strategies in Dermatology

Seborrheic Dermatitis: Principles of Seborrheic Dermatitis Management

Principles of Seborrheic Dermatitis Management Seborrheic dermatitis is a chronic intermittent condition. There is an initial treatment period followed by maintenance therapy. Many patients will relapse if maintenance therapy is not adequate. Topi…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…atocytes of an otherwise preserved epidermis. The diagnosis of Langerhans cell histiocytosis (LCH) was made based on morphologic criteria and confirmed by positivity of abnormal Langerhans cells by anti-CD1a and anti-S100 immunostains and negativity…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…. Rather than trying to kll the highly dysplastic or malignant cells directly, a benign cell booster increases the fitness of the more benign cells, which may be either normal or benign clones, so that they may outcompete more advanced or malignant c…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

…unders Co., 1992:210. “It is well documented that nevus cells can be found within the fibrous capsule and trabeculae of lymph nodes; however, it is less well known that nevus cells can also b found in the lymph node parenchyma.” Biddle…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Invasion by Neoplastic Cells?

…i.e., cancer, exhibits the properties of: 1. invasion when its cells infiltrate the surrounding normal tissue; and 2. metastasis, the capacity of cancer cells to spread and grow at sites distant from the origin of the neoplasm.” Harnden DG, Mc…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…e and innumerable myelinated nerves, makes contact with Merkel cells that reside in the basal layer of the epidermis. Merkel cells are neuroendocrine ones that are present in human skin. That is not the case, however, for the hair disk; it has not be…

Differential Diagnosis in Dermatopathology

Dermatofibroma with "monster" cells vs. Malignant fibrous histiocytoma

A proliferation of abnormal Langerhanscells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Therapeutic Strategies in Dermatology

Candidiasis: Initial Evaluation

Initial Evaluation Candidiasis Intertriginous Oral Paronychia Differential diagnosis Inverse pityriasis rosea Deficiency dermatitis (such as zinc deficiency, aka acrodermatitis enteropathica) Allergic or irritant cont…