Dermatology Practical & Conceptual

From the Dermatologikum Hamburg

…avy dermal infiltrate of neutrophils with variable degrees of leukocytoclasis but no vasculitis [1,4]. Fibrinoid degeneration of collagen, resembling the collagen changes present in rheumatoid nodules in a miniaturized form also has been reported [5]…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…in the lumen of some small vessels, degeneration of collagen, leukocytoclasis, and confluent epidermal necrosis = Response to the “bite” of a spider This dermatitis in the form of perivascular and interstitial mixed-cell infiltrates, smal…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…them, is characterized histopathologically by the presence of leukocytoclasis, that is, nuclear “dust” of neutrophils in company with intact neutrophils and, in lesions developed fully, with fibrin in the wall of venules. In septic vascul…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…onecrotic variant of PLEVA, where lymphocytic vasculitis with leukocytoclasis is a fairly common feature.” Mobini N, Toussaint S, Kamino H. Noninfectious erythematous, papular, and squamous diseases. In: Elder DE, Elenitsas R, Johnson BL, et a…

Differential Diagnosis in Dermatopathology

Discussions

…itis and eosinophils often are conspicuous in it, but neither leukocytoclasis nor eosinophils is present in septic vasculitis; thrombi develop in septic vasculitis, but not in allergic vasculitis; arterioles, as well as venules, are affected in septi…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…Allergic (leukocytoclastic) vasculitis Septic vasculitis 1. Leukocytoclasis, i.e., nuclear “dust” of neutrophils invariable and abundant usually 1. No nuclear “dust” of neutrophils 2. Fibrin in and around the wall of venul…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema elevatum diutinum

…is accompaniment of it by fragments of nuclei of neutrophils (leukocytoclasis). 10.58.23A: Fibrosing dermatitis + 10.58.23B: Thin bundles of collagen in fascicles that interweave and scattered neutrophils and nuclear “dust” of t…