Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…histopathologic Early Superficial perivascular infiltrate of lymphocytes Lichenoid infiltrate of lymphocytes, patchy at first and then confluent Infiltrate obscures the dermoepidermal junction in conjunction with vacuolar alteration and individual…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…cimen was taken, as evidenced by the nearly pure population of lymphocytes, rather than the dense infiltrate of neutrophils that appeared soon after the “bite.” 10.5.30A: Nodular dermatitis, mixed-cell + 10.5.30B: Lymphocytes an…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…monos (single) + morphe (form)], examples of that being small lymphocytes in the inflammatory disease called polymorphous light eruption, abnormal lymphocytes in some lymphomas, and mast cells in the benign neoplasm urticaria pigmentosa. An infiltra…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…gn neoplasm of keratocytes being what induced the onslaught of lymphocytes that leads eventually to destruction of the keratosis. 11.11.2A: Perivascular dermatosis, lichenoid + 11.11.2B: Lymphocytes, jagged acanthosis, necrotic keratocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…the upper part of the reticular dermis may consist entirely of lymphocytes, as in Schamberg”s disease (see Fig. 5.25), of lymphocytes and eosinophils, as in a type of drug eruption (see Fig. 5.28), and of lymphocytes, neutrophils, and eosinophi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…+ 10.60.5B: Obscuration of the dermoepidermal junction by lymphocytes, clefts, jagged acanthosis, hypergranulosis, and orthokeratosis = Lichen planus, early┬áIn an early lesion of lichen planus, the lichenoid infiltrate of lymphocytes is focal; i…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…sect “bite” by the presence of distinctly abnormal lymphocytes, i.e., ones that are large, pleomorphic, and often marked further by cerebriform outline. Nucleoli are prominent in some of those lymphocytes, mitotic figures are present in o…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…company there with scant spongiosis; neither nuclear atypia of lymphocytes nor collections of lymphocytes are encountered consistently in flat or slightly raised lesions of mycosis fungoides. Error: Benign cephalic histiocytosis, benign mucous membra…