Therapeutic Strategies in Dermatology

Persistent Pigmented Purpuric Dermatitis: Overview

Overview This group of diseases includes Schamberg’s disease, purpura annularis telangiectodes (of Majocchi), lichenoid pigmented purpura (of Gougerot and Blum), eczematoid purpura of Doucas and Kapetanakis (disseminated pruriginous angioderma…

Therapeutic Strategies in Dermatology

Sarcoidosis: Overview

…ulmonary disease, uveitis, hepatosplenomegaly, and disfiguring skin lesions. Patients with multisystem disease are best managed by a team of appropriate specialists. The therapeutic strategy is empiric, and its purpose is to suppress granuloma format…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Actinic Granuloma?

…ternal or environmental origin and distinguishes it from other granulomas with which it is constantly being confused.” O’Brien P. Actinic granuloma: an annular connective tissue disorder affecting sun and heat damaged (elastotic) skin. A…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…lteration in the vessel wall and in the extravascular collagen system. This tissue alteration, common to all cases here reported, comprised necrosis of eosinophilic exudate, severe “fibrinoid” collagen change, and granulomatous proliferat…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyogenic granuloma

…f as macules/patches and nodules/tumors, as well as papules. A single papule of bacillary angiomatosis, hemangioma, and Kaposi’s sarcoma may be indistinguishable from one of pyogenic granuloma. Findings histopathologic Early Small polypoid ma…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma faciale

Granuloma faciale Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the face Shape of lesions Round or oval usually Individual lesions Papules, plaques, nodules, or tumors marked on their surface often…

Differential Diagnosis in Dermatopathology

Papular mucinosis vs Interstitial granuloma annulare

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…