Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Therapeutic Strategies in Dermatology

Lichen Planus: Key Points

…d rarely of the skin, may be complicated by the development of squamous cell carcinoma. Lichen planus may be triggered by or found in association with exogenous factors, such as medications or contact allergens; a treatable cause should always be sou…

Therapeutic Strategies in Dermatology

Warts: Treatment

…ted with HPV 16 or 18, and histologically may show features of squamous cell carcinoma in situ. Total eradication of these lesions should be attempted. They are treated in the same manner as genital warts. 5-Fluorouracil (5-FU) topically can be effec…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa/ Mastocytosis: Overview

…GI complaints, and headaches can result from circulating mast cell products released when the mastocytoma is rubbed or irritated. These symptoms may require treatment. Treatment First steps Children with localized mast cell tumors are best treated b…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

Malignant neoplasms of B-lymphocytes especially that present themselves usually as papules, nodules, and tumors, sometimes solitary but at other times numerous, and often in clusters on any anatomic site. When “primary,” B-cell lymphomas o…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Extramammary Paget’s/Paget’s Disease: Overview

…y Paget’s is almost always associated with an underlying carcinoma. The data on extramammary Paget’s are less clear, but between 25% and 50% have an associated carcinoma. A careful lymph node evaluation is essential. Immunoperoxidase mark…