Differential Diagnosis in Dermatopathology

Lupus profundus vs. Morphea profundus

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Differential Diagnosis in Dermatopathology

Scleroderma (morphea) vs. Scleredema (Buschke)

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Therapeutic Strategies in Dermatology

Keloids and Hypertrophic Scars: Treatment

…keloid-like lesions includes inflammatory conditions such as morphea and xanthomas, growths such as sarcomas, and even infections such as lobomycosis. If the lesion is symptomatic. If the lesion is not improving with multiple intralesional corticost…

A Clinical Atlas of 101 Common Skin Diseases

Basal Cell Carcinoma

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…atrophicans, necrobiosis lipoidica (Fig. 3.359 A&B), and morphea (Fig. 5.360 A&B). At a late stage in the life of a lesion of necrobiosis lipoidica, collagen bundles may be thickened and crowded in a manner reminiscent highly of that of morp…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…of other colleagues, lichen sclerosus et atrophicus simply is morphea restricted mostly to a thickened papillary dermis, but affecting also the uppermost part of the reticular dermis by changes characteristic of classic morphea. When morphea involves…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nd plasma cells in the interstitium of the reticular dermis = Morphea, early  The changes shown represent an early stage in a longstanding inflammatory process, i.e., before any alterations in collagen bundles have become recognizable. When, after ye…

Differential Diagnosis in Dermatopathology

Discussions

…wn also as collagenoma, and in a lesion late in the course of morphea, abnormalities of connective tissue are observed mostly in the dermis. Bundles of collagen are thickened throughout the reticular dermis and often in septa of the subcutaneous fat….

Differential Diagnosis in Dermatopathology

Discussions

…e deliberately; lichen sclerosis et atrophicus is superficial morphea. Morphea is one of the sclerodermas and lichen sclerosus et atrophicus is that manifestation of morphea which affects the uppermost part of the reticular dermis, a thickened papill…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lymphoma” is nothing other than “small-plaque par…