Differential Diagnosis in Dermatopathology

Lupus profundus vs. Morphea profundus

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Differential Diagnosis in Dermatopathology

Scleroderma (morphea) vs. Scleredema (Buschke)

A disease manifested chiefly in the skin by vesicles and bullae that appear on sites of trauma, especially the face and dorsa of the hands, often in conjunction with macular hyperpigmentation and hypertrichosis of a face and sclerodermoid changes on…

Therapeutic Strategies in Dermatology

Keloids and Hypertrophic Scars: Treatment

Treatment First-line therapy: Intralesional corticosteroids remain the first-line therapy for keloids and hypertrophic scars. They may be effective in 50-100% of cases but may be associated with recurrence in up to half of cases. Treatment of keloid…

A Clinical Atlas of 101 Common Skin Diseases

Basal-Cell Carcinoma

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…a atrophicans, necrobiosis lipoidica (Fig. 3.359 A&B), and morphea (Fig. 5.360 A&B). At a late stage in the life of a lesion of necrobiosis lipoidica, collagen bundles may be thickened and crowded in a manner reminiscent highly of that of mor…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen sclerosus et atrophicus

…of other colleagues, lichen sclerosus et atrophicus simply is morphea restricted mostly to a thickened papillary dermis, but affecting also the uppermost part of the reticular dermis by changes characteristic of classic morphea. When morphea involve…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…plasma cells among collagen bundles in the reticular dermis = Morphea, earlyAt this early stage in the evolution of the process, no changes in bundles of collagen are detectable. In short, although a longstanding lesion of morphea is barren of infla…

Differential Diagnosis in Dermatopathology

Discussions

…ocytes and plasma cells may be present even at a late stage of morphea. No inflammatory cells are seen, however, in a collagenous nevus. Orientation of collagen bundles is crucial for distinguishing a late lesion of morphea from a collagenous nevus….

Differential Diagnosis in Dermatopathology

Discussions

…ne deliberately; lichen sclerosis et atrophicus is superficial morphea. Morphea is one of the sclerodermas and lichen sclerosus et atrophicus is that manifestation of morphea which affects the uppermost part of the reticular dermis, a thickened papil…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…being. Error: Atrophoderma of Pasini and Pierini differs from morphea. Reason: The atrophoderma named eponymically for Pasini and Pierini simply is the end stage of morphea, a phenomenon that has counterparts clinical and histopathologic. Error: Atr…