Histologic Diagnosis of Inflammatory Skin Diseases

Dermatomyositis

…tle vacuolar alteration and an occasional necrotic keratocyte Mucin increased slightly in the reticular dermis Venules of the superficial plexus dilated Epidermis slightly thinned focally Nuclei of keratocytes of thinned epidermis sometimes pleomorph…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…r and interstitial dermatosis + 11.18.1B: Large amount of mucin in company with scattered spindle- and stellate-shaped fibrocytes, as well as mast cells = Scleromyxedema, early ┬áThis is an early lesion because mucin is so abundant in the reticula…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

…granulomas reminiscent of those named for Churg and Strauss) Mucin detectable sometimes in foci of palisaded granulomas Correlation clinicopathologic The cord is formed by dense diffuse, often “bottom-heavy” infiltrates composed mostly…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…ack skin” looks like parapsoriasis en plaques. Alopecia mucinosa (mycosis fungoides with epithelial mucinosis) consists of patches and plaques studded with infundibulocentric papules, the lesions having a predilection for the face, neck and sca…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus Versus Systemic Lupus Erythematosus?* I

…us erythematosus, lupus tumidus, and reticulated erythematous mucinosis. The skin lesions of “neonatal lupus erythematosus” simply are those of lupus erythematosus in a newborn. By microscopy, classic discoid lupus erythematosus is seen t…

Histologic Diagnosis of Inflammatory Skin Diseases

Nodular fasciitis

…, an elongated tail of cytoplasm; some multinucleate Abundant mucin in the zone of fibrosing granulation tissue Mixture of inflammatory cells scattered throughout the fibrosing granulation tissue Extravasated erythrocytes and siderophages often Late…

Differential Diagnosis in Dermatopathology

Granuloma annulare vs. Necrobiosis lipoidica

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…

Differential Diagnosis in Dermatopathology

Pretibial myxedema vs. Scleromyxedema

An inflammatory process that expresses itself in the skin in protean ways that are variations on a basic pathologic theme, and includes evanescent patches on the face (“butterfly blush”), scaly papules and plaques that resolve with atrop…