Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

Capability for accurate diagnosis of inflammatory skin diseases, clinically and histopathologically, requires familiarity thoroughly with embryologic, histologic, and anatomic aspects of the skin. Although examples of this precept are legion, only a…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

….37.9B: A pustule in a single locus situated immediately above muscles of hair erection = Suppurative infundibulitis of unknown cause From the presence of muscles of hair erection beneath an intraepidermal pustule, it may be inferred that the process…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

General Balkwill F (ed). Cytokine Cellular Biology: A Practical Approach (Practical Approach Series). Oxford: Oxford University Press, 2000. Darmon M, Blumenberg M (eds). Molecular Biology of the Skin: The Keratinocyte. San Diego: Academic Press, 19…

Histologic Diagnosis of Inflammatory Skin Diseases

Topography and Regional Variation

The skin of infants is traversed by a subtle maze of ridges that develops during the fourth and fifth months of fetal life. The ridges become increasingly prominent during childhood. Those surface markings remain stable throughout life and are nearl…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

A sebaceous gland, a lipid-producing epithelial structure, develops in the fourth month of fetal life from a protuberance of epithelium that lies between the uppermost protrusion, which represents the future apocrine unit, and the lower bulge, which…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

Both somatic sensory and autonomic motor nerves are present in skin (Fig. 1.82). The somatic sensory system mediates sensations of pain, itch, temperature, light touch, discriminative touch, pressure, vibration, and proprioception. Nerves of the aut…

Histologic Diagnosis of Inflammatory Skin Diseases

Lipodystrophy

Lipodystrophy Synonyms Lipoatrophy Wucher atrophy Presentation stereotypical Age and sex Females, first decade of life Distribution of lesions Upper half of body in the “partial” expression of the process and widespread in the “t…