Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atopic Dermatitis?

…the word neurodermatitis is the sense of a role for cutaneous nerves in the pathogenesis of that supposed disease of the skin. In fact, that was the belief of those who first introduced the term “neurodermatitis,” to wit, that alteration…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Blue Nevus?

…interlaced ribbons with large knots of voluminous [or bulky] nerves . . .” Masson P. Système Mélanogène. In: Tumeurs Humaines: HistologieDiagnostic et Techniques [Human tumors: histology, diagnosis and techniques]. Paris, France: Librairie Ma…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ltrate of lymphocytes and histiocytes in and around cutaneous nerves and adnexal epithelium in the deep reticular dermis 4. No infiltrate of inflammatory cells in nerves or adnexal epithelium usually 5. Cutaneous nerves often missing consequent to…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Myxoma?

…benign neoplasm not of mucin but stromal cells of peripheral nerves. Parenthetically, both “intramuscular myxoma” and “cardiac myxoma” represent deposits of mucin rather than benign neoplasms. Astonishingly, myxoma also is em…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…borderline leprosy are indications that the patient is in reaction. Involvement of nerves by lymphocytes is not, in itself, a sign of a reactional state; lymphocytes sometimes are present in nerves of leprous persons who are not in reaction….

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…ics, collagen, elastic fibers, ground substance, muscles, and nerves. The strategy is to inform about how the skin looks by examination grossly and by inspection using conventional microscopy, and how it works. Although each of the components of the…

Histologic Diagnosis of Inflammatory Skin Diseases

Nail Units

…otect the terminal phalanges. A network of myelinated sensory nerves in the dermis of the nail bed, some nerves of which terminate near Merkel cells within the epithelium of the nail bed, enables the nail unit to contribute to appreciation of fine ta…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…ereby creating a link between the nervous and immune systems. Nerves, by virtue of release from them of neuropeptides, such as calcitonin gene-related peptide, are able to modulate the function of Langerhans”cells. In sections stained by hemato…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…nnective tissue. Sebaceous glands are not innervated by motor nerves. The mite, Demodex folliculorum, is present commonly not only within infundibula, but also within sebaceous ducts of infundibuloapocrine-sebaceous-follicular units positioned on the…

Dermatology Practical & Conceptual

Dermoscopic findings in a patient with multiple piloleiomyomas

…in could result from local pressure by the tumor on cutaneous nerves [3]. The main differential diagnosis consists of other dermal nodular lesions like dermatofibroma, eruptive syringoma, angiolipoma, neurilemoma, endometrioma, leiomyosarcoma, glomus…