Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…f inflammatory cell that predominates in the infiltrate, i.e., neutrophils or lymphocytes. Small-vessel vasculitis that involves venules is incomparably more common than that which affects arterioles, and small-vessel vasculitis in which neutrophils

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

…round space that housed a hair in the midst of a collection of neutrophils (Fig. 5.312 A&B), another is the finding of a muscle of hair erection in contiguity with a small abscess, and yet another is splaying, in a rather discrete locus, of neutr…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…es and/or plasma cells (Fig. 5.179 A&B) and, episodically, neutrophils mostly. On occasion a nodular dermatitis (or panniculitis) may consist of but a single large nodule made up of neutrophils almost exclusively (an abscess) (Fig. 5.180 A&B)…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…scular and interstitial dermatitis + 10.63.14B: Scatter of neutrophils and nuclear “dust” of neutrophils in the upper part of the dermis, edema of the papillary dermis, and a smudged appearance, in foci, of the dermoepidermal junction…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.88.1A: Perivascular dermatitis, neutrophils predominant + 10.88.1B: Neutrophils in edematous dermal papillae = Prurigo pigmentosa ¬†Findings similar to these may be seen in dermatitis herpetiformis at a very early stage of the pr…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatitis herpetiformis

…nfiltrate of lymphocytes mostly and interstitial infiltrate of neutrophils mostly Edema of the papillary dermis Neutrophils, nuclear bands of neutrophils, and nuclear “dust” of neutrophils in linear array immediately beneath the dermoepid…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

…bular epidermis. Clues to specific diagnosis histopathologic Neutrophils in a discrete focus in what appears to be surface epidermis is a clue to the possibility of suppurative infundibulitis being adjoining. A collection of neutrophils atop a stra…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…al mixed-cell infiltrate of lymphocytes around venules mostly; neutrophils and eosinophils scattered interstitially especially Edema of the papillary dermis Lymphocytes in company with neutrophils and/or eosinophils sprinkled along the dermoepidermal…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…in extrusion of its contents, including a hair shaft and many neutrophils, into the reticular dermis. The bluish cast of the collagen represents degeneration of it, a consequence of the effects of lysosomal enzymes released from neutrophils. 1…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es 10.102.1A: Perivascular and interstitial dermatitis, neutrophils mostly + 10.102.1B: Neutrophils accompanied by scant nuclear “dust” but by edema marked in the papillary dermis = Sweet’s syndrome ¬†This can be judged to…