Histologic Diagnosis of Inflammatory Skin Diseases

Lichen simplex chronicus/Prurigo nodularis/Picker’s nodule/Erosions/Ulcers

…ented, and traversed by accentuated skin markings; papules and nodules in prurigo nodularis; and eroded and/or ulcerated papules and nodules in picker’s nodule. Variations clinical Lichen simplex chronicus may be imposed on primary pruritic de…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

Rheumatoid nodule Presentation stereotypical Age and sex Children and adults, more often females Distribution of lesions Near joints, especially elbows, and along bony structures, particularly extensor surfaces of forearms Individual lesions Nodules…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…. A patch may become a plaque or upon it may develop a papule, nodule, or tumor. A papule may develop into a nodule or tumor. The surface of an elevated lesion of melanoma tends to be uneven. When a melanoma is no longer flat, it has capability to me…

A Clinical Atlas of 101 Common Skin Diseases

Dermatofibrosarcoma Protuberans

…s, face, and scalp. A papule of it tends to become a plaque, a nodule, a tumor, or all of them concurrently. Sometimes a plaque is interspersed with many nodules and tumors in a cluster. The sarcoma is “low grade,” i.e., it metastasizes onl…

A Clinical Atlas of 101 Common Skin Diseases

Basal Cell Carcinoma

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…odular dermatitides the infiltrates are dense, i.e., they form nodules many times more replete with cells than are the infiltrates of a perivascular dermatitis. The nodules, just like their much less robust counterparts in perivascular dermatitis, ar…

Differential Diagnosis in Dermatopathology

Discussions

…hereas it often is formidable late in the course of rheumatoid nodule. Rheumatoid nodule usually extends deep into the subcutaneous fat, whereas granuloma annulare does not. In subcutaneous granuloma annulare, vasculitis of small vessels in the form…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…of degenerated collagen mostly but also in fibrin = Rheumatoid nodule ¬†Although fibrin usually forms the core of the palisaded granuloma typical of rheumatoid nodule, at times the center consists mainly of degenerated collagen, as is the case here. L…