Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides

A malignant neoplasm made up of abnormal germinative cells analogous to those that compose the folliculosebaceous-apocrine germ in an embryo and that usually manifests clinically as a papule or nodule which may become ulcerated. On the basis of clin…

A Clinical Atlas of 101 Common Skin Diseases

Lymphomas (Other Than Mycosis Fungoides and Lymphomatoid Papulosis)

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been arrest…

Therapeutic Strategies in Dermatology

Kaposi’s Sarcoma: Overview

…Overview Kaposi’s sarcoma (KS) results from endothelial cell proliferation caused by infection with human herpesvirus 8 and occurs in four settings: classic KS, African (endemic) KS, immunosuppressive-associated KS, and AIDS-associated KS. The…

Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

Overview Therapy of cutaneous T-cell lymphoma often requires specialized knowledge, and for this reason it is often appropriate to refer such patients to a medical center with specialized knowledge in the management of CTCL. Since early aggressive t…

Therapeutic Strategies in Dermatology

Candidiasis: Treatment

…ion affecting intertrigious sites that results from friction. Pale erythematous, macerated plaques are the clinical hallmarks of intertrigo, and they are typically KOH negative. Reduction of friction and inflammation (with topical corticosteroids) is…

Differential Diagnosis in Dermatopathology

Pale-cell acanthoma vs. Psoriasis, plaque expression

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Dermatology Practical & Conceptual

Large cell acanthoma: a debate throughout the decades

Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? In 1970, large cell acanthoma (LCA) was first described by Pinkus, as a sharply demarc…

Differential Diagnosis in Dermatopathology

"Pseudolymphoma," B-cell type vs. Malignant lymphoma, B-cell type

…in clusters on any anatomic site. When “primary,” B-cell lymphomas of the skin seem to be wholly cutaneous with no evidence of extracutaneous manifestations after complete staging has been performed. The major categories of primary cutaneou…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…common. Lichtenstein failed, however, to note the distinctive cell that truly was the denominator in common of the three conditions—one that in sections stained by hematoxylin and eosin sports a large pale reniform nucleus and abundant amphophi…