Therapeutic Strategies in Dermatology

Pediculosis (Lice): Initial Evaluation

Initial Evaluation The lice, eggs, or nits (empty egg casings) are not always obviously visualized. Important clues include excoriated erythematous papules (shown in this image) or maculae ceruleans (slate-blue macules) on areas of skin that come in…

Therapeutic Strategies in Dermatology

Scabies: Suggested Reading

Suggested Reading Currie BJ and McCarthy JS (2010) Permethrin and Ivermectin for scabies, NEJM, 362: 717-725….

Dermatology Practical & Conceptual

Pre-emptive diagnosis of a case of scabies by dermatopathology

…on.” He made the additional comment: “Two apparent scabies mites are present” (Figure 3). Figure 3. Dermatopathology image of the pigmented skin lesion shown in the previous images showing two apparent scabies mites at the level…

Differential Diagnosis in Dermatopathology

Nodular scabies vs. Lymphomatoid papulosis

An inflammatory process caused by the acarus Sarcoptes scabiei and consisting of papules, papulovesicles, papulopustules, and vesicles, some arranged in linear or curvilinear tracks (burrows). Sometimes nodules are present, especially in the interdi…

A Clinical Atlas of 101 Common Skin Diseases

Arthropod Assaults

Papules, nodules, vesicles, and sometimes bullae that develop in response to “bites” of arthropods, among the most common offenders being mosquitoes, bedbugs, and mites of scabies….

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…tire length of the intraepidermal burrow is vesicular. Nodular scabies refers to longstanding papules in which no mite or progeny of her is detectable by microscopy conventional. Keratotic-crusted (Norwegian) scabies describes a highly contagious exp…

Histologic Diagnosis of Inflammatory Skin Diseases


…0.5.13B: Ova of mites within a burrow in the cornified layer = Scabies The infiltrate consists of lymphocytes, plasma cells, and eosinophils, all of which are expected in a lesion of scabies. 10.5.14A: Perivascular and interstitial dermatitis +…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…ytes, plasma cells, and eosinophils, as is the case in nodular scabies (Fig. 5.198). Not uncommonly in that particular manifestation of scabies in which no sign of the mite, her progeny, or her detritus is apparent in the stratum corneum, large lymph…

Differential Diagnosis in Dermatopathology


…me lymphocytes is much more notable than it ever is in nodular scabies. Lymphocytes in lymphomatoid papulosis are larger and more pleomorphic than those in nodular scabies, have prominent nucleoli, often are multinucleate, and even may display aberra…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…