Differential Diagnosis in Dermatopathology

Discussions

The interstitial expression of granuloma annulare and of papular mucinosis have several findings histopathologic in common, among them mesenchymal cells with abundant pink cytoplasm scattered among bundles of collagen, multinucleate cells in section…

Differential Diagnosis in Dermatopathology

Discussions

In a collagenous type of connective tissue nevus, known also as collagenoma, and in a lesion late in the course of morphea, abnormalities of connective tissue are observed mostly in the dermis. Bundles of collagen are thickened throughout the reticu…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Differential Diagnosis in Dermatopathology

Discussions

A major source of confusion in differentiation of scleroderma and scleredema is terminology, the names of the wholly dissimilar conditions being so similar. Moreover, both diseases are associated with alterations of collagen in the dermis. The impor…

Differential Diagnosis in Dermatopathology

Images

Pretibial myxedema Scleromyxedema

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Pretibial myxedema Scleromyxedema 1. Epidermis slightly thickened and often hyperkeratotic 1. Epidermis normal or only slightly hyperplastic 2. Abnormalities mostly in the upper half of the dermis in lesions developed fully 2. Abnormalities th…