Differential Diagnosis in Dermatopathology

Pemphigus vulgaris vs. Grover’s disease, pemphigus vulgaris-like

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus-like keratosis

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Therapeutic Strategies in Dermatology

Vitiligo: Treatment

Treatment Localized disease, <5% body surface area First-line therapy: Topical treatment options include a mid- to superpotent topical steroid (such as betamethasone or clobetasol) applied twice daily to the skin. Evidence supports that this is…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.11.1A: Perivascular dermatosis, lichenoid + 11.11.1B: Lymphocytes, many necrotic keratocytes and a subepidermal cleft = Lichen planus-like keratosis, early  Because lichen planus-like keratosis often is misinterpreted clinically…

Histologic Diagnosis of Inflammatory Skin Diseases

Behçet’s Disease

…hem. Erythema nodosum-like lesions of Behçet”s syndrome, like those of erythema nodosum, display mixed-cell infiltrates that in septa are accompanied by marked edema. Those infiltrates, like ones in early lesions of erythema nodosum, consist mo…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…