Histologic Diagnosis of Inflammatory Skin Diseases

Acne vulgaris

…abscesses that take the form of nodules associated often with sinus tracts and fistulae, those draining to the surface of the skin. Each component of the triad may appear alone or in conjunction with another or with both components of it. 3. Tropical…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…phoplasmacytic infiltrates and fibrosis at the periphery of a sinus = Hidradenitis suppurativa Changes just like these are seen in acne conglobata and acne keloidalis. Note well the sinus formed by infundibular epithelium near the base of the sec…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…before. That particular pattern is encountered most often in sinus histiocytosis with massive lymphadenopathy, but it may be seen, at times, in the absence of any lymphadenopathy. 10.24.3A: Nodular dermatitis, mixed-cell + 10.24….

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…dden infections were recommended, including evaluation of the sinuses, tonsils, teeth, gallbladder, fallopian tubes and prostate. Presumably the patient develops an allergic or mediator-driven reaction to some bacterial product; perhaps toxic effects…

Differential Diagnosis in Dermatopathology

Acne vulgaris, erythematous papule vs. Rosacea, erythematous papule

A disease of infundibulosebaceous units, especially infundibula, that may manifest itself solely as noninflammatory lesions, i.e., comedones and intact cysts, or as inflammatory lesions, i.e., papules, nodules, and pustules. The process may resolve…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…t often 9. No comedones or milia 10. Infundibular cysts and sinus tracts may be accompaniments 10. No infundibular cysts or sinus tracts 11. Telangiectasias not remarkable 11. Telangiectasias often striking 12. Little or no solar elastosis 12….

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

…iated with cells whose nuclei show prominent abnormalities. Sinus histiocytosis with massive lymphadenopathy (Destombes-Rosai-Dorfman syndrome) is made up of large, pale histiocytes that with immunoperoxidase stain are S-100 positive, and dense, pa…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…granulomatous lesions in upper air passages (nose, paranasal sinuses, nasopharynx, glottis . . .) or in the lower respiratory tract (trachea, bronchi, lungs) or in both. 2. Generalized focal necrotizing vasculitis involving both arteries and veins,…

Differential Diagnosis in Dermatopathology

Discussions

…te, in years, in pitted or hypertrophic scars or in tenacious sinus tracts of “acne conglobata.” Comedones traditionally have been described as “open” (blackheads) or “closed” (whiteheads). In actuality, a comedo i…