Histologic Diagnosis of Inflammatory Skin Diseases

Acne vulgaris

…When suppurative infundibulitis of acne vulgaris is extensive, sinus tracts come into existence as infundibular epidermis proliferates in a valiant effort to contain the sea of neutrophils that envelops it. When sinuses form in severe acne vulgaris o…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…mphoplasmacytic infiltrates and fibrosis at the periphery of a sinus = Hidradenitis suppurativa Changes just like these are seen in acne conglobata and acne keloidalis. Note well the sinus formed by infundibular epithelium near the base of the se…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.24.1A: Nodular and diffuse dermatitis, granulomatous + 10.24.1B: Lymphocytes and plasma cells in a collection of histiocytes that exhibit abundant pale cytoplasm = Destombes-Rosai-Dorfman disease Histiocytes with lar…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

“. . . we are justified in arranging, provisionally at least, the dermatoses possibly due to focal infection in six groups, as follows: Group 1: Those considered in some relation with arthropathy:            1, erythema nodosum; 2, erythema…

Differential Diagnosis in Dermatopathology

Acne vulgaris, erythematous papule vs. Rosacea, erythematous papule

A disease of infundibulosebaceous units, especially infundibula, that may manifest itself solely as noninflammatory lesions, i.e., comedones and intact cysts, or as inflammatory lesions, i.e., papules, nodules, and pustules. The process may resolve…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…nt often 9. No comedones or milia 10. Infundibular cysts and sinus tracts may be accompaniments 10. No infundibular cysts or sinus tracts 11. Telangiectasias not remarkable 11. Telangiectasias often striking 12. Little or no solar elastosis 12….

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

Subcutaneous T-cell lymphoma Synonyms Subcutaneous panniculitis-like lymphoma Presentation stereotypical Age and sex Mostly women in the third and fourth decades of life Distribution of lesions Extremities, trunk, face, neck, and breasts Arrangement…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

“Inside the nose besides extensive necrosis, there is a cell-rich granulomatous tissue with granulomatous epithelioid cell foci which surround the vessels. . . . In both lungs: infarct-like necrosis in which one finds severe changes in the ve…

Differential Diagnosis in Dermatopathology

Discussions

Erythematous papules of acne vulgaris and of rosacea have in common localization mostly to the face, suppurative infundibulitis, and a mixed infiltrate of inflammatory cells in the dermis, it containing lymphocytes and plasma cells, and sometimes hi…